2,6-双(4-甲氧基苯基)吡喃鎓高氯酸盐 | 21172-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2,6-双(4-甲氧基苯基)吡喃鎓高氯酸盐
• 英文名称: 2,6-Bis(p-methoxyphenyl)pyrylium perchlorate
• 英文别名: 2,6-bis(4-methoxyphenyl)pyrylium perchlorate；2,6-Bis(4-methoxyphenyl)pyrylium-perchlorat；2,6-di(4-methoxyphenyl)pyrylium perchlorate；2,6-Di-p-methoxyphenylpyrilium perchlorate；2,6-di-p-methoxyphenylpyrylium perchlorate；2,6-bis-(4-methoxy-phenyl)-pyranylium; perchlorate；2,6-Di(p-methoxyphenyl)pyrylium perchlorate；2,6-bis(4-methoxyphenyl)pyrylium;perchlorate
• CAS: 21172-76-9
• 化学式: C₁₉H₁₇O₃*ClO₄
• 分子量: 392.793
• InChiKey: ZZLHKUXAQKEYTR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.16
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,6-双(4-甲氧基苯基)吡喃鎓高氯酸盐 在 盐酸 、 正丁基锂 作用下， 以 乙醚 为溶剂， 反应 1.5h， 生成 1,5-bis(4-methoxyphenyl)-3-phenylethynyl-1,5-pentanedione
  参考文献：
  名称：

  Koblik, A. V.; Murad'yan, L. A., Russian Journal of Organic Chemistry, 1995, vol. 31, # 2, p. 245 - 253

  摘要：

  DOI：
• 作为产物：
  描述：

  原甲酸三乙酯 、 对甲氧基苯乙酮 在 高氯酸 作用下， 以86%的产率得到2,6-双(4-甲氧基苯基)吡喃鎓高氯酸盐
  参考文献：
  名称：

  The relative electron donating ability of substituents, determined in 2,6-disubstituted pyrylium cations

  摘要：

  The carbon-13 NMR spectra of a series of 2,6-disubstituted pyrylium compounds have been investigated. The chemical shift of C(4) is a measure of the charge density in that position of the ring. The variation of the chemical shift with the change of substituent is determined by the ability of substituents to delocalize the positive charge from C(4), an effect which for substituents at C(2) and C(6) is free from any other shielding or deshielding effects. The electron-donating ability of substituents vary in the order: H < i-Pr < Me < p-ClC6H4 < p-FC6H4 less-than-or-equal-to Ph << 2-thienyl less-than-or-equal-to c-Pr less-than-or-equal-to p-MeOC6H4. The ordering of alkyl groups indicates that C-H hyperconjugation is stronger than C-C hyperconjugation. For the aryl substituents the chemical shifts are correlated linearly with the partial rate factor (log (P(f)) for the protiodesilylation of the parent arenes. The ability of cyclopropyl to delocalize the positive charge is similar to that of 2-thienyl and p-anisyl.

  DOI：

  10.1021/jo00001a025

文献信息

• Pharmacological properties of pyridinium salts, pyrazolines, and pyrazoles
  作者：É. A. Zvezdina、M. P. Zhdanova、I. I. Nechayuk、I. A. Barchan、Yu. N. Simkina、T. A. Buchnaya

  DOI：10.1007/bf00763700

  日期：1986.11

  6]; drugs have also been found among pyrazoline and pyrazole derivatives [8]. This work presents information on the investigation of the antimicrobial, neurotropic, and fungicidal action of pyridinium salts (III), bis-pyridinium salts (IV), pyrazolines (V), and pyrazolo[l,5-c]pyrimidine (VI), produced in the recyclization of 2,6-diarylpyrilium perchlorates (I) under the action of amines, semi-, and

  根据文献资料，吡啶盐具有广谱的抗菌作用[3, 6]；在吡唑啉和吡唑衍生物中也发现了药物[8]。这项工作提供了有关吡啶鎓盐 (III)、双吡啶鎓盐 (IV)、吡唑啉 (V) 和吡唑并 [1,5-c] 嘧啶 (VI) 的抗微生物、神经营养和杀真菌作用的研究信息，由 2,6-二芳基吡啶鎓高氯酸盐 (I) 在胺、半氨基和氨基硫脲作用下再循环产生。
• One-Pot Synthesis of 2,6-Di-<i>t</i>-butyl- and 2,6-Diarylthiopyrylium Perchlorates
  作者：Giancarlo Doddi、Gianfranco Ercolani

  DOI：10.1055/s-1985-31351

  日期：——

  The title compounds were prepared by reaction of the corresponding methyl ketone with an excess of triethyl orthoformate in an acidic medium (acetic anhydride/perchloric acid) under a hydrogen sulfide stream.

  标题化合物是通过在酸性介质（乙酸酐/高氯酸）中，在硫化氢流的作用下，将相应的甲基酮与过量的原甲酸三甲酯反应而制备的。
• Orlov, V. D.; Vakula, V. N.; Gella, I. M., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, # 8, p. 1570 - 1575
  作者：Orlov, V. D.、Vakula, V. N.、Gella, I. M.

  DOI：——

  日期：——
• Regitz, Manfred; Khbeis, Saad G., Chemische Berichte, 1984, vol. 117, # 6, p. 2233 - 2246
  作者：Regitz, Manfred、Khbeis, Saad G.

  DOI：——

  日期：——
• Reynolds, G. A.; Chen, C. H., Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1235 - 1237
  作者：Reynolds, G. A.、Chen, C. H.

  DOI：——

  日期：——