2-(1-吡啶-2-基乙烯基)吡啶 | 54416-76-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(1-吡啶-2-基乙烯基)吡啶
• 英文名称: 2,2'-(ethene-1,1-diyl)dipyridine
• 英文别名: Pyridine, 2,2'-ethenylidenebis-；2-(1-pyridin-2-ylethenyl)pyridine
• CAS: 54416-76-1
• 化学式: C₁₂H₁₀N₂
• 分子量: 182.225
• InChiKey: VXXRMBQHVJKWIC-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  200 °C(Press: 17 Torr)
• 密度：
  1.082±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-吡啶-2-基乙烯基)吡啶 生成 2-methylidene-8,11-diazoniatricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene;dibromide;hydrate
  参考文献：
  名称：

  ECKHARD I. F.; SUMMERS L. A., AUSTRAL. J. CHEM. , 1974, 27, NO 11, 2511-2513

  摘要：

  DOI：
• 作为产物：
  描述：

  2-二吡啶基酮 、 亚甲基三苯基膦烷 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 2-(1-吡啶-2-基乙烯基)吡啶
  参考文献：
  名称：

  Discovery of 6,11-Ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium Cations, a Novel Class of N-Methyl-D-aspartate Antagonists

  摘要：

  6,11-Ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium cations 8, a novel class of N-methyl-D-aspartate (NMDA) antagonists acting at the phencyclidine site, have been identified. Structure-activity relationship studies around the lead compound 8a led to the identification of 12g (WIN 67870-2), one of the most potent compounds in this series. Compound 12g has a K-i = 1.8 +/- 0.2 nM vs [H-3]TCP binding, has 700-fold selectivity for binding to the open state of the NMDA receptor-ionophore, and was devoid of MK-801- and PCP-like behavioral effects in rats. Compound 12g was neuroprotective in cultured mouse cortical neurons and exhibited antiischemic activity in a rat middle cerebral artery occlusion/reperfusion model of focal ischemia.

  DOI：

  10.1021/jm00001a006

文献信息

• Alkenyl Arenes as Dipolarophiles in Catalytic Asymmetric 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides
  作者：Ana Pascual-Escudero、Abel de Cózar、Fernando P. Cossío、Javier Adrio、Juan C. Carretero

  DOI：10.1002/anie.201609187

  日期：2016.12.5

  The use of alkenyl arenes as dipolarophiles in the catalytic asymmetric 1,3‐dipolar cycloaddition of azomethine ylides is reported. Under appropriate reaction conditions with a CuI or AgI catalyst either the exo or the endo adduct was obtained with high stereoselectivity. This process provides efficient access to highly enantiomerically enriched 4‐aryl proline derivatives. The observed results are

  据报道，烯基芳烃在偶氮甲亚胺的催化不对称1,3-偶极环加成反应中用作双极性亲和剂。在适当的反应条件下，用Cu I或Ag I催化剂以高的立体选择性获得外型或内型加合物。此过程可有效获取高度对映体富集的4-芳基脯氨酸衍生物。观察到的结果与1,3-偶极的一个前手性面的阻滞，以及亲电性向亲双性分子的末端碳原子的有效传递是兼容的。这种极化导致从协调机制到逐步机制的转变。
• Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies
  作者：James McNulty、Chanti Babu Dokuburra、Leonardo D'Aiuto、Matthew Demers、Lora McClain、Paolo Piazza、Kelly Williamson、Wenxiao Zheng、Vishwajit L. Nimgaonkar

  DOI：10.1016/j.bmcl.2020.127559

  日期：2020.12

  The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.

  报道了先导抗病毒环丙基羧基酰基腙 4F17 ( 5 ) 和结构类似物的三个序列阵列的合成，以及针对 1 型单纯疱疹病毒 (HSV-1) 的抗病毒药效团的初步评估和优化。
• [EN] METHOD FOR FLUORESCENCE LABELING OF BIOLOGICAL MATERIALS, THERMALLY REMOVABLE FLUORESCENT LABELS FOR THIS METHOD, AND METHODS OF THEIR PREPARATION AND USE<br/>[FR] PROCÉDÉ DE MARQUAGE PAR FLUORESCENCE DE MATÉRIAUX BIOLOGIQUES, MARQUEURS FLUORESCENTS ÉLIMINABLES PAR VOIE THERMIQUE DESTINÉS À CE PROCÉDÉ ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：FUTURESYNTHESIS SPOLKA Z O O

  公开号：WO2020117079A1

  公开（公告）日：2020-06-11

  The compounds (12), (13) of the invention are applied as thermosensitive fluorescent labels for labeling of biological material with fluorescent dyes used for biological, chemical or physical analyzes. Disclosed is also a method for fluorescence labeling of nucleosides, nucleotides and oligonucleotides with those fluorescent dyes characterized in that a moiety of general formula 1 or 2 or 3 or 4 with the double bond configuration E is attached to a nucleoside nucleotide or oligonucleotide.

  本发明的化合物（12），（13）被应用为热敏荧光标记物，用于使用于生物、化学或物理分析的荧光染料对生物材料进行标记。还公开了一种荧光标记核苷、核苷酸和寡核苷酸的方法，其中这些荧光染料的特征是将通式1或2或3或4的基团与具有双键构型E的核苷、核苷酸或寡核苷酸结合。
• [EN] DESFERRIOXAMINE CONJUGATES, DERIVATIVES AND ANALOGUES<br/>[FR] CONJUGUÉS DE LA DESFERRIOXAMINE, DÉRIVÉS ET ANALOGUES
  申请人：UNIV SYDNEY

  公开号：WO2009055863A1

  公开（公告）日：2009-05-07

  The present invention relates to desferoxamine conjugates, derivatives and analogues thereof. In particular, the present invention relates to desferoxamine conjugates, analogues and derivatives thereof, and methods for reducing levels of metals, especially iron, in a mammal. Uses of the compounds according to the invention are also provided. Compounds of the present invention may also be used to treat iron dyshomeostasis disorders, cancer, malaria and fungal infections. The compounds of the invention may be formulated into a pharmaceutical composition or packaged into kits.

  本发明涉及去氧胺酸共轭物、衍生物及类似物。具体而言，本发明涉及去氧胺酸共轭物、类似物和衍生物，以及在哺乳动物中降低金属水平，特别是铁的方法。本发明还提供了根据本发明的化合物的用途。本发明的化合物还可用于治疗铁失调疾病、癌症、疟疾和真菌感染。本发明的化合物可制成药物组合物或打包成套装。
• The Sn–C bond reactivity in 1,1-bis(heteroaryl)-2-triorganostannylethanes toward tungsten carbonyl derivatives
  作者：Geng-Wen Yin、Huan Yang、Wei-Yi Guo、Liang-Fu Tang

  DOI：10.1016/j.jorganchem.2018.11.029

  日期：2019.2

  refluxing THF resulted in the oxidative addition of the inactive R3Sn–C bond to the tungsten atom to yield metal-metal bonded complexes CH2CH(3,5-Me2Pz)2W(CO)3SnR3. While reaction of R3SnCH2CH(mim)2 (R = n-Bu or Ph; mim = 1-methylimidazol-2-yl) with W(CO)6 in refluxing dioxane gave only the decarbonylation complexes R3SnCH2CH(mim)2W(CO)4, no analogous oxidative addition of the R3Sn–C bond was observed

  R 3 SnCH 2 CH（3,5-Me 2 Pz）2（R =  n- Bu，CH 2 Ph或Ph; Pz =吡唑-1-基）与W（CO）5 THF在回流的THF中反应灭活的R 3 Sn–C键与钨原子的氧化加成反应生成金属-金属键合的配合物CH 2 CH（3,5-Me 2 Pz）2 W（CO）3 SnR 3。R 3 SnCH 2 CH（mim）2（R =  n- Bu或Ph; mim = 1-甲基咪唑-2-基）与W（CO）6的反应在回流的二恶烷中，仅给出了脱羰基络合物R 3 SnCH 2 CH（mim）2 W（CO）4，未观察到类似的R 3 Sn-C键氧化加成反应。此外，R中的反应3 SNCH 2 CH（PY）2（R =  Ñ -Bu或pH; PY = 2-吡啶基）朝向W（CO）5 THF显着地依赖于取代基R的脱羰络合物（ñ -当R代表n时，得到Bu）3 SnCH 2 CH（py）2 W（C