2-(1-甲基环丙基)甘氨酸 | 58160-96-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(1-甲基环丙基)甘氨酸
• 英文名称: 2-(Cyclopropylmethylazaniumyl)acetate
• CAS: 58160-96-6
• 化学式: C6H11NO2
• mdl: MFCD11185552
• 分子量: 129.16
• InChiKey: JOWMUWBEMDOCKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] ANILINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS<br/>[FR] DERIVES D'ANILINE UTILISES COMME MODULATEURS DU RECEPTEUR SELECTIF DE L'ANDROGENE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005085185A1

  公开（公告）日：2005-09-15

  This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

  这项发明涉及非类固醇化合物，这些化合物是雄激素、糖皮质激素、矿物质皮质激素和孕激素受体的调节剂，并涉及制备和使用这些化合物的方法。
• Pharmacologically active peptides, their preparation and pharmaceutical compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0030847A2

  公开（公告）日：1981-06-24

  Compounds of the formula and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D definethe chirality; R, is hydrogen or C1-C3 primary alkyl; R2 is C1-C4 primary or secondary alkyl, allyl, cyclopropylmethyl, C1-C2 hydroxyalkyl, or -(CH2)m-U-CH3 in which U is -S- or and m is 1 or2; R3 is cyclopropylmethyl or allyl; and Z is in which R4 is hydrogen, acetyl, or acetoxymethyl and Rs is C1-C3 alkyl; are useful analgesic agents. These compounds of formula I are prepared by deblocking the correspondingly blocked tetrapeptide offormula I.

  式中的化合物 及其药学上可接受的无毒酸加成盐，其中 L 和 D 定义手性； R 是氢或 C1-C3 伯烷基； R2 是 C1-C4 伯烷基或仲烷基、烯丙基、环丙基甲基、C1-C2 羟烷基或-(CH2)m-U-CH3，其中 U 是-S-或 而 m 是 1 或 2； R3 是环丙基甲基或烯丙基；以及 Z 是 其中 R4 是氢、乙酰基或乙酰氧甲基，Rs 是 C1-C3 烷基；这些都是有用的镇痛剂。式 I 的这些化合物是通过解锁式 I 中相应的受阻四肽而制备的。
• Pharmacologically active pentapeptide derivatives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0050503A1

  公开（公告）日：1982-04-28

  Compounds of the formula and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, or ethyl; A is the residue of a D-amino acid selected from Ala, Abu, Nva, Val, Nle, Leu, Ile, Gly(Al), Gly(Cp), Met, Cys(Me), Met(O), Cys(Me) (0), Ser, Thr, and Hse; R1 is hydrogen, C1-C3 primary alkyl, cyclopropylmethyl, allyl, or propargyl; X is bromo, iodo, chloro, C1-C3 alkyl, trifluoromethyl, or C1-C2 alkoxy; B is the residue of a D- or L-amino acid lacking its carboxyl moiety and selected from Gly, Ala, Abu, Nva, Val, Nle, Leu, lie, Pgl, Cys(Me), Cys(Me) (0), Cys(Me) (02), Cys(Et), Cys(Et) (0), Cys(Et) (02), Met, Met(O), Met(O2), Eth, Eth(O), Eth(O2), Ser(Me), Ser(Et), Hse(Me), and Hse(Et) as well as any of such residues substituted at the amino nitrogen by a C1-C3 primary alkyl; Z is -CH2OR2, in which R2 is hydrogen or C1-C3 alkyl; subject to the proviso that, when R1 is other than hydrogen, B is the residue of an amino acid that lacks substitution at the amino nitrogen; which are useful analgesic agents, are described.

  式化合物 及其药学上可接受的无毒酸加成盐，其中 R 是氢、甲基或乙基； A 是 D-氨基酸的残基，选自 Ala、Abu、Nva、Val、Nle、Leu、Ile、Gly(Al)、Gly(Cp)、Met、Cys(Me)、Met(O)、Cys(Me) (0)、Ser、Thr 和 Hse； R1 是氢、C1-C3 伯烷基、环丙基甲基、烯丙基或丙炔基； X 是溴、碘、氯、C1-C3 烷基、三氟甲基或 C1-C2 烷氧基； B 是缺少羧基的 D-或 L-氨基酸的残留物，选自 Gly、Ala、Abu、Nva、Val、Nle、Leu、lie、Pgl、Cys(Me)、Cys(Me) (0)、Cys(Me) (02)、Cys(Et)、Cys(Et) (0)、Cys(Et) (02)、Met、Met(O)、Met(O2)、Eth、Eth(O)、Eth(O2)、Ser(Me)、Ser(Et)、Hse(Me) 和 Hse(Et) 以及在氨基氮处被 C1-C3 伯烷基取代的任何此类残基；Z 是-CH2OR2、 其中 R2 是氢或 C1-C3 烷基；但条件是，当 R1 不是氢时，B 是氨基酸的残基，该残基在氨基氮处没有被取代；这些都是有用的镇痛剂。
• Pharmacologically active tetrapeptide derivatives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0050502A1

  公开（公告）日：1982-04-28

  Compounds of the formula and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, ethyl, cyclopropylmethyl, or allyl; A is a residue of a D-amino acid selected from Ala, Abu, Nva. Val, Nle, Leu, lie, Gly(A1), Gly(Cp), Met, Cys(Me), Met(O), Cys(Me) (0), Ser, Thr, and Hse; R1 is C1-C3 primary alkyl, cyclopropylmethyl, allyl, ethylthiomethyl, 2-fluoroethyl, or propargyl; X is bromo, iodo, chloro, methyl, trifluoromethyl, or methoxy; and or in which R2 is hydrogen, acetyl, or acetoxymethyl and R3 is C1-C3 alkyl; which are useful analgesic agents, are described herein.

  式化合物 及其药学上可接受的无毒酸加成盐，其中 R 是氢、甲基、乙基、环丙基甲基或烯丙基； A 是选自 Ala、Abu、Nva.Val、Nle、Leu、lie、Gly(A1)、Gly(Cp)、Met、Cys(Me)、Met(O)、Cys(Me) (0)、Ser、Thr 和 Hse； R1 是 C1-C3 伯烷基、环丙基甲基、烯丙基、乙硫基甲基、2-氟乙基或丙炔基； X 是溴、碘、氯、甲基、三氟甲基或甲氧基；以及 或 其中 R2 是氢、乙酰基或乙酰氧甲基，R3 是 C1-C3 烷基；这些都是有用的镇痛剂，在此进行描述。
• Pharmacologically active peptides
  申请人：ELI LILLY AND COMPANY

  公开号：EP0112036A1

  公开（公告）日：1984-06-27

  Novel C-terminal keto tripeptides, similar in structure to enkephalin, are useful analgesic agents.

  与脑啡肽结构相似的新型 C 端酮三肽是有用的镇痛剂。