2-(1-羟基-2-三甲基铵基乙基)-3-氧代月桂酸酯 | 1492-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-(1-羟基-2-三甲基铵基乙基)-3-氧代月桂酸酯
• 英文名称: decanoylcarnitine
• 英文别名: 3-decanoyloxy-4-(trimethylazaniumyl)butanoate
• CAS: 1492-27-9
• 化学式: C₁₇H₃₃NO₄
• 分子量: 315.453
• InChiKey: LZOSYCMHQXPBFU-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] NOVEL CRYSTALLINE FORMS<br/>[FR] NOUVELLES FORMES CRISTALLINES
  申请人：GRUENENTHAL CHEMIE

  公开号：WO2017195031A1

  公开（公告）日：2017-11-16

  Preparation and characterization of novel forms of (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid, suitable for pharmaceutical compositions in drug delivery systems for humans.

  制备和表征新型(1-羟基-2-咪唑-1-基-1-膦酸乙基)膦酸，适用于人类药物输送系统中的药用组合物。
• [EN] STABLE INDOLE-3-PROPIONATE SALTS OF S-ADENOSYL-L-METHIONINE<br/>[FR] SELS D'INDOLE-3-PROPIONATE STABLES DE LA S-ADÉNOSYL-L-MÉTHIONINE
  申请人：HEBERT SAM E LLC

  公开号：WO2014113609A1

  公开（公告）日：2014-07-24

  Stable indole-3-propionic acid salts of S-adenosyl-L-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical compositions comprising the indole-3-propionic acid salts, methods of using the indole-3-propionic acid salts and processes for making same.

  本发明公开了稳定的S-腺苷甲硫氨酸的吲哚-3-丙酸盐，或其药用可接受的盐，以及包含吲哚-3-丙酸盐的药物组合物，使用吲哚-3-丙酸盐的方法和制备方法。
• Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments
  申请人：Merck & Co., Inc.

  公开号：EP0215697A2

  公开（公告）日：1987-03-25

  Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.

  酰基肉碱可用作鼻腔、口腔、舌下和阴道药物吸收促进剂，用于吸收不良的药物。
• Acyl carnitine esterase, production thereof and method for analyzing acyl carnitines
  申请人：ASAHI KASEI KOGYO KABUSHIKI KAISHA

  公开号：EP0480676A2

  公开（公告）日：1992-04-15

  An acylcarnitine esterase which has a substrate specificity to acyl-L-carnitines including short chain acyl-L-carnitines inclusive of acetyl-L-carnitine and propionyl-L-carnitine and which catalyzes the hydrolysis reaction of one mole of the acyl-L-carnitines with one mole of water to form one mole of the corresponding fatty acid and one mole of L-carnitine.

  一种酰基肉碱酯酶，它对酰基-L-肉碱（包括乙酰基-L-肉碱和丙酰基-L-肉碱在内的短链酰基-L-肉碱）具有底物特异性，可催化一摩尔酰基-L-肉碱与一摩尔水的水解反应，生成一摩尔相应的脂肪酸和一摩尔 L-肉碱。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。