2-(1-羟基乙基)硫胺焦磷酸盐 | 20319-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-(1-羟基乙基)硫胺焦磷酸盐
• 英文名称: 2-(1-Hydroxyethyl)thiamine pyrophosphate
• 英文别名: 2-[2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethoxy]ethyl phosphono hydrogen phosphate;chloride
• CAS: 20319-27-1
• 化学式: C14H23ClN4O8P2S
• 分子量: 504.8
• InChiKey: GFOZNKHLFXWLSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.14
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  206
• 氢给体数：
  4
• 氢受体数：
  13

文献信息

• ALIPHATIC AMINO ACID BIOSYNTHESIS INHIBITORS AND A METHOD OF SYNTHESIZING THE SAME
  申请人：Sardari Soroush

  公开号：US20130289104A1

  公开（公告）日：2013-10-31

  The embodiments herein provide a composition and a method of synthesizing a composition comprising an aliphatic amino acid biosynthesis inhibitor having an antifungal activity. The composition comprises 2-oxo-2H-chromen-7-yl propiolate, diethyl-hex-2-en-4-yne-dioate and dinonyl-hex-2-en-4-yne-dioate. The composition inhibits a biosynthesis of an aliphatic amino acid in a fungal biological system. The aliphatic amino acid is selected from a group consisting of leucine, isoleucine and valine. The composition is used with a concentration of 0-200 μg/ml. The method comprises mixing solutions of dicyclohexylcarbodiimide (DCC) and Dimethylaminopyridine (DMAP) with alcohol, acetylene carboxylic acid and dichloromethane to obtain a mixture which is stirred filtered and washed with ether. The solvents are evaporated to obtain a residue that is dissolved in dichloromethane and stirred with a catalyst. The extra solvents are evaporated to obtain the derivative compound and purified by silica gel column chromatography.

  本文提供了一种合成含有具有抗真菌活性的脂肪族氨基酸生物合成抑制剂的组合物和合成组合物的方法。该组合物包括2-氧代-2H-香豆素-7-基丙炔酸酯、二乙基-己-2-烯-4-炔二酸酯和二辛基-己-2-烯-4-炔二酸酯。该组合物在真菌生物系统中抑制脂肪族氨基酸的生物合成。脂肪族氨基酸选自亮氨酸、异亮氨酸和缬氨酸等一组氨基酸。该组合物的使用浓度为0-200μg/ml。该方法包括将二环己基碳二亚胺（DCC）和二甲基氨基吡啶（DMAP）的溶液与醇、乙炔羧酸和二氯甲烷混合，以获得混合物，该混合物经过搅拌、过滤和乙醚洗涤。然后蒸发溶剂以获得残留物，该残留物在二氯甲烷中溶解并与催化剂搅拌。额外的溶剂被蒸发以获得衍生物化合物，并通过硅胶柱层析纯化。
• Herbicide resistant products based on structure-based method
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1754786A2

  公开（公告）日：2007-02-21

  Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.

  本发明公开了用于制备乙酰羟肟酸合成酶（AHAS）变体的基于结构的建模方法，包括那些对除草剂如咪唑啉类除草剂和AHAS抑制性除草剂表现出选择性抗性增强的变体。本发明包括编码此类变体的分离 DNA、包含 DNA 的载体、生产变体多肽和含有特定 AHAS 基因突变的抗除草剂植物的方法。本发明还提供了控制农作物杂草的方法。
• Enterobacter sp-638 and methods of use thereof
  申请人：Newman Lee

  公开号：US10645934B2

  公开（公告）日：2020-05-12

  The present invention relates to a novel species of Enterobacter, Enterobacter sp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture of Enterobacter sp. 638, to the plant.

  本发明涉及一种新型的肠杆菌--肠杆菌 638，以及其用途，例如，与未施用本发明方法或组合物的情况下在相同条件下生长的对照或野生型植物相比，本发明涉及一种提高植物生长、提高植物生物量、提高植物果实和/或种子产量、提高植物耐病性和/或抗性、提高植物耐旱性和/或抗性的方法。这些方法包括向植物施用有效量的组合物，其中包括肠杆菌 638 的分离培养物。
• ANTIBODY-MEDIATED COFACTOR-DRIVEN REACTIONS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0540687A1

  公开（公告）日：1993-05-12
• EP0540687A4
  申请人：——

  公开号：EP0540687A4

  公开（公告）日：1993-10-13