2-(1H-1,2,4-三唑-1-基甲基)苯胺 | 127988-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(1H-1,2,4-三唑-1-基甲基)苯胺
• 英文名称: 2-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine
• 英文别名: 2-[(1,2,4-Triazol-1-yl)methyl]aniline；2-(1,2,4-triazol-1-ylmethyl)aniline
• CAS: 127988-21-0
• 化学式: C₉H₁₀N₄
• mdl: MFCD09025845
• 分子量: 174.205
• InChiKey: CBGQHZNXHUCAGE-UHFFFAOYSA-N

物化性质

• 熔点：
  62-63 °C(Solv: ethyl ether (60-29-7))
• 沸点：
  402.5±47.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-(1H-1,2,4-三唑-1-基甲基)苯胺 在 sodium tetrahydroborate 作用下， 以 乙醇 、 苯 为溶剂， 反应 26.0h， 生成 N-(4-fluorobenzyl)-2-(1H-1,2,4-triazol-1-ylmethyl)benzeneamine
  参考文献：
  名称：

  Synthesis and antimycotic activity of new (1H-1,2,4-triazol-1-yl-methyl)benzeneamine derivatives

  摘要：

  DOI：

  10.1016/0223-5234(89)90059-7
• 作为产物：
  描述：

  (1H-1,2,4-triazol-1-ylmethyl)-2-nitrobenzene 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 60.0 ℃ 、101.32 kPa 条件下， 以70%的产率得到2-(1H-1,2,4-三唑-1-基甲基)苯胺
  参考文献：
  名称：

  Synthesis and antimycotic activity of new (1H-1,2,4-triazol-1-yl-methyl)benzeneamine derivatives

  摘要：

  DOI：

  10.1016/0223-5234(89)90059-7

文献信息

• Compositions for the filling of high aspect ratio vertical interconnect access (VIA) holes
  申请人：Heraeus Precious Metals North America Conshohocken LLC

  公开号：US11289238B2

  公开（公告）日：2022-03-29

  A solvent-free electroconductive composition may be used to make electroconductive lines on a surface of a substrate or electroconductive plugs within via holes of a substrate. The solvent-free electroconductive composition is generally made of about 40 to about 95 wt % of a conductive component, about 4 to about 30 wt % of a polymer or oligomer comprising a reactive functional group, up to about 20 wt % of a monomeric diluent comprising a reactive functional group, and up to about 3 wt % of a curing agent. In some instances, the solvent-free electroconductive composition further includes up to about 3 wt % of a lubricating compound. Substrates made using solvent-free electroconductive compositions may be used in printed circuit boards, integrated circuits, solar cells, capacitors, resistors, thermistors, varistors, resonators, transducers, inductors, and multilayer ferrite beads.

  无溶剂导电组合物可用于在基材表面制作导电线或在基材通孔内制作导电塞。无溶剂导电组合物一般由约 40 至约 95 wt % 的导电成分、约 4 至约 30 wt % 含有活性官能团的聚合物或低聚物、最多约 20 wt % 含有活性官能团的单体稀释剂和最多约 3 wt % 的固化剂组成。在某些情况下，无溶剂导电组合物还包括最多约 3 wt % 的润滑化合物。使用无溶剂导电组合物制成的基板可用于印刷电路板、集成电路、太阳能电池、电容器、电阻器、热敏电阻器、压敏电阻器、谐振器、传感器、电感器和多层铁氧体磁珠。
• SCALZO, MARCELLO;BIAVA, MARIANGELA;CERRETO, FELICE;PORRETTA, GIULIO CESAR+, EUR. J. MED. CHEM., 24,(1989) N, C. 537-540
  作者：SCALZO, MARCELLO、BIAVA, MARIANGELA、CERRETO, FELICE、PORRETTA, GIULIO CESAR+

  DOI：——

  日期：——
• COMPOUNDS
  申请人：Medical Research Council Technology

  公开号：US20170320870A1

  公开（公告）日：2017-11-09

  A compound of formula I, or a pharmaceutically acceptable salt or ester thereof, wherein R 1 is selected from: aryl; heteroaryl; —NHR 3 ; fused aryl-C 4-7 -heterocycloalkyl; —CONR 4 R 5 ; —NHCOR 6 ; —C 3-7 -cycloalkyl; —O—C 3-7 -cycloalkyl; —NR 3 R 6 ; and optionally substituted —C 1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C 4-7 -heterocycloalkyl and C 4-7 -heterocycloalkyl are each optionally substituted; R 2 is selected from hydrogen, aryl, C 1-6 -alkyl, C 2-6 -alkenyl, C 3-7 -cycloalkyl, heteroaryl, C 4-7 heterocycloalkyl and halogen, wherein said C 1-6 -alkyl, C 2-6 -alkenyl, aryl, heteroaryl and C 4-7 -heterocycloalkyl are each optionally substituted; R 3 is selected from aryl, heteroaryl, C 4-7 -heterocycloalkyl, C 3-7 -cycloalkyl, fused aryl-C 4-7 -heterocycloalkyl and C 1-6 -alkyl, each of which is optionally substituted; R 4 and R 5 are each independently hydrogen, or optionally substituted C 3-7 -cycloalkyl, aryl, heteroaryl, C 1-6 -alkyl or C 3-6 -heterocycloalkyl; or R 4 and R 5 together with the N to which they are attached form a C 3-6 -heterocycloalkyl ring; each R 6 is independently selected from C 1-6 -alkyl, C 3-7 cycloalkyl, C 4-7 -heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted each R 7 is selected from hydrogen, optionally substituted C 1-6 -alkyl and C 3-7 -cycloalkyl; each of R 8 and R 9 is independently hydrogen or optionally substituted C 1-6 -alkyl; or R 8 and R 9 together with the N to which they are attached form a C 4-6 -heterocycloalkyl; each R 10 is selected from C 3-7 -cycloalkyl and optionally substituted C 1-6 -alkyl; each R 11 is independently selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkyl-C 3-7 -cycloalkyl, C 4-7 -heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, —NR 4 SO 2 R 5 , —CN, —OR 6 , —NR 4 R 5 , —NR 7 R 11 , hydroxyl, —CF 3 , —CONR 4 R 5 , —NR 4 COR 5 , —NR 7 (CO)NR 4 R 5 , —NO 2 , —CO 2 H, —CO 2 R 6 , —SO 2 R 6 , —SO 2 NR 4 R 5 , —NR 4 COR 5 ,—NR 4 COOR 5 , C 1-6 -alkyl and —COR 6 . Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formula I.
• COMPOSITIONS FOR THE FILLING OF HIGH ASPECT RATIO VERTICAL INTERCONNECT ACCESS (VIA) HOLES
  申请人：Heraeus Precious Metals North America Conshohocken LLC.

  公开号：US20210174983A1

  公开（公告）日：2021-06-10

  A solvent-free electroconductive composition may be used to make electroconductive lines on a surface of a substrate or electroconductive plugs within via holes of a substrate. The solvent-free electroconductive composition is generally made of about 40 to about 95 wt % of a conductive component, about 4 to about 30 wt % of a polymer or oligomer comprising a reactive functional group, up to about 20 wt % of a monomeric diluent comprising a reactive functional group, and up to about 3 wt % of a curing agent. In some instances, the solvent-free electroconductive composition further includes up to about 3 wt % of a lubricating compound. Substrates made using solvent-free electroconductive compositions may be used in printed circuit boards, integrated circuits, solar cells, capacitors, resistors, thermistors, varistors, resonators, transducers, inductors, and multilayer ferrite beads.
• Synthesis and antimycotic activity of new (1H-1,2,4-triazol-1-yl-methyl)benzeneamine derivatives
  作者：Marcello Scalzo、Mariangela Biava、Felice Cerreto、Giulio Cesare Porretta、Rinaldo Mercantini、Corrado Fanelli

  DOI：10.1016/0223-5234(89)90059-7

  日期：1989.9