2-(2,4-二氯苯氧基)乙酸乙酯 | 1039828-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2,4-二氯苯氧基)乙酸乙酯
• 英文名称: ethyl 2-(2, 4-dichlorophenoxy) acetate
• 英文别名: Ethyl 2-(2-butan-2-ylphenoxy)acetate
• CAS: 1039828-13-1
• 化学式: C₁₄H₂₀O₃
• mdl: MFCD11174612
• 分子量: 236.311
• InChiKey: NRIDGDPBNYSFHZ-UHFFFAOYSA-N

物化性质

• 熔点：
  112-113 °C
• 沸点：
  317.5±25.0 °C(Predicted)
• 密度：
  1.014±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2,4-二氯苯氧基)乙酸乙酯 在 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 (2-仲丁基苯氧基)乙酸
  参考文献：
  名称：

  Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

  摘要：

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.040
• 作为产物：
  描述：

  2-仲丁基苯酚 、 溴乙酸乙酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 4.0h， 生成 2-(2,4-二氯苯氧基)乙酸乙酯
  参考文献：
  名称：

  Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

  摘要：

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.040

文献信息

• Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
  作者：Koneni V. Sashidhara、Gopala Reddy Palnati、Ranga Prasad Dodda、Ravi Sonkar、A.K. Khanna、Gitika Bhatia

  DOI：10.1016/j.ejmech.2012.09.040

  日期：2012.11

  A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia. (C) 2012 Elsevier Masson SAS. All rights reserved.