2-(2,5-二氧代哌嗪-1-基)乙酸 | 98135-15-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(2,5-二氧代哌嗪-1-基)乙酸
• 中文别名: 1-哌嗪乙酸,2,5-二羰基-
• 英文名称: 2,5-dioxo-1-piperazineacetic acid
• 英文别名: (2,5-Dioxopiperazin-1-YL)acetic acid；2-(2,5-dioxopiperazin-1-yl)acetic acid
• CAS: 98135-15-0
• 化学式: C₆H₈N₂O₄
• 分子量: 172.141
• InChiKey: XYXLNYSVQVWRQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,5-dioxo-1-piperazineacetic acid 1,1-dimethylethyl ester 以 苯甲醚 、 乙腈 为溶剂， 生成 2-(2,5-二氧代哌嗪-1-基)乙酸
  参考文献：
  名称：

  2-Acylaminopropanamides as growth hormone secretagogues

  摘要：

  这项发明提供了一系列替代丙酰胺，可用于治疗可能通过增加生长激素而调节的生理状况。该发明还提供了治疗这种生理状况的方法，包括联合使用本发明中描述的生长激素分泌促进剂和生长激素释放激素。

  公开号：

  EP0761220A1

文献信息

• 2-acylaminopropanamides as tachykinin receptor antagonists
  申请人：Eli Lilly and Company

  公开号：US05565568A1

  公开（公告）日：1996-10-15

  This invention provides a series of novel substituted propanamides which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disorders as well as pharmaceutical formulations which employ these novel compounds.

  本发明提供了一系列新型取代丙酰胺，这些化合物在治疗或预防与速激肽过量相关的生理障碍方面具有应用价值。本发明还提供了治疗此类生理障碍的方法以及使用这些新型化合物的药物配方。
• 2-acylaminopropanamides as growth hormone secretagogues
  申请人：Eli Lilly and Company

  公开号：US05773441A1

  公开（公告）日：1998-06-30

  This invention provides a series of novel substituted propanamides which are useful in the a physiological condition which may be modulated by an increase in growth hormone. This invention also provides methods for the treatment of such physiological conditions which comprise administering a growth hormone secretagogue as described in the present invention in combination with growth hormone releasing hormone.

  这项发明提供了一系列新颖的替代丙酰胺类化合物，这些化合物在可能通过增加生长激素来调节的生理状况中具有用处。该发明还提供了治疗这种生理状况的方法，包括在与生长激素释放激素结合的情况下，给予本发明中描述的生长激素分泌促进剂。
• Method of preparing amino carboxylic acids
  申请人：——

  公开号：US20020002281A1

  公开（公告）日：2002-01-03

  Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

  提供了一种新型化合物，即N,N'-双(膦甲基)-N,N'-双(羟基甲酰甲基)脲和N,N,N',N'-四(羟基甲酰甲基)脲，适用于制备可轻松转化为N-(膦甲基)甘氨酸的N-酰基氨基羧酸。这些化合物可以通过在羧甲基化催化剂前体和溶剂存在下，将双(膦甲基)脲或脲分别与一氧化碳和甲醛反应而形成。
• Process for absorption of sulfur compounds from fluids using certain piperidines, piperazines, or anhydrides of monocarboxylic amino acids
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0471592A2

  公开（公告）日：1992-02-19

  Sulfur dioxide is removed from a fluid containing SO2 by employing as an absorbent for the SO2 an aqueous solution of a compound represented by Formulae I, II or III : wherein each Y is independently -(CR22)- or -(CR2)= ; each R1, R2, R5 or R6 is independently hydrogen, an alkyl group ; an hydroxyalkyl group ; an aldehyde group ; a carboxylic acid group or salt thereof ; or an alkyl group containing at least one carboxylic acid ester, a carboxylic acid or salt thereof, ether, aldehyde, ketone, or sulfoxide group ; wherein at least one of R1 and R2 and at least one of R5 and R6 is a carbonyl-containing group ; each R3 or R4 is independently hydrogen ; an alkyl group ; a hydroxyalkyl group ; an aldehyde group ; a carboxylic acid or salt group ; or an alkyl, aryl, or aralkyl group containing at least one carboxylic ester, a carboxylic acid or salt, ether, aldehyde, ketones or sulfoxide group. The absorbent solution preferably can be thermally regenerated by heating to remove SO2.

  通过使用由式 I、II 或 III 所代表的化合物的水溶液作为二氧化硫的吸收剂，从含有二氧化硫的流体中去除二氧化硫： 其中每个 Y 独立地为-(CR22)-或-(CR2)＝；每个 R1、R2、R5 或 R6 独立地为氢、烷基、羟烷基、醛基、羧酸基或其盐、或含有至少一个羧酸酯、羧酸或其盐、醚、醛、酮或亚砜基的烷基；其中 R1 和 R2 中的至少一个以及 R5 和 R6 中的至少一个是含羰基的基团；每个 R3 或 R4 独立地是氢；烷基；羟烷基；醛基；羧酸或盐基；或含有至少一个羧酸酯、羧酸或盐、醚、醛、酮或亚砜基团的烷基、芳基或芳烷基。吸收剂溶液最好可以通过加热进行热再生，以去除二氧化硫。
• 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP0819005A1

  公开（公告）日：1998-01-21