1-(2-morpholin-4-ylethyl)-3-[(E)-1-pyridin-2-ylethylideneamino]thiourea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1-(2-morpholin-4-ylethyl)-3-[(E)-1-pyridin-2-ylethylideneamino]thiourea
• 化学式: C₁₄H₂₁N₅OS
• 分子量: 307.42
• InChiKey: VOQXNVBTBFFGOA-SFQUDFHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Antiviral combinations
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0135713A2

  公开（公告）日：1985-04-03

  The invention as claimed herein relates to synergistic combinations of nucleoside analogues, which are converted to viral DNA polymerase inhibitors through the action of at least one virus-induced enzyme, and thiosemicarbazone ribonucleotide reductase inhibitors. These combinations are especially useful in combatting herpes virus infections.

  本发明涉及核苷类似物与硫代氨基甲酸核糖核苷酸还原酶抑制剂的协同组合，核苷类似物可通过至少一种病毒诱导酶的作用转化为病毒 DNA 聚合酶抑制剂。 这些组合尤其有助于防治疱疹病毒感染。
• Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
  申请人：——

  公开号：US20010008905A1

  公开（公告）日：2001-07-19

  A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse- transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.

  一种抑制植物或动物细胞中依赖逆转录酶病毒复制的方法，包括给所述细胞施用一种化合物，该化合物能消耗细胞内的脱氧核苷磷酸池，其有效量能抑制所述病毒的复制。羟基脲就是这样一种合适的化合物。还公开了一种产生不完全逆转录酶依赖性病毒 DNA 的方法，其方法是给感染了这种病毒的细胞施用一种磷酸脱氧核苷类药物。
• Therapeutic DNA vaccination
  申请人：——

  公开号：US20020022034A1

  公开（公告）日：2002-02-21

  A method for genetic immunization comprises administering a highly active antiretroviral therapy to control viral replication, and then administering a transcutaneous DNA vaccine.

  基因免疫方法包括使用高活性抗逆转录病毒疗法来控制病毒复制，然后使用经皮 DNA 疫苗。
• Hydroxyurea treatment for spinal muscular atrophy
  申请人：——

  公开号：US20030040543A1

  公开（公告）日：2003-02-27

  The invention features a method of modulating SMN exon 7 expression in a subject by administering hydroxyurea to the subject.

  本发明的特点是通过对受试者施用羟基脲来调节受试者体内 SMN 外显子 7 表达的方法。
• Method of inducing autovaccination against HIV infection using structured treatment interruptions
  申请人：——

  公开号：US20030095988A1

  公开（公告）日：2003-05-22

  Structured Treatment Interruptions of drug therapy for Human Immunodeficiency Virus infection can be used to enhance HIV-specific immune responses, thereby allowing the individual to control viral replication after interrupting the drug treatment. Immunoregulatory adjuvants can further increase these immune responses. A diagnostic method for the immune status of the patient that controls HIV includes measurements of viral load and production of both IFN-gamma and IL-10.

  中断人类免疫缺陷病毒感染的药物治疗可用于增强艾滋病毒特异性免疫反应，从而使患者在中断药物治疗后仍能控制病毒复制。 免疫调节佐剂可进一步增强这些免疫反应。 控制艾滋病毒患者免疫状态的诊断方法包括测量病毒载量以及 IFN-gamma 和 IL-10 的产生。