2-(2-吡啶-2-基乙烯基)吡嗪 | 66806-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-(2-吡啶-2-基乙烯基)吡嗪
• 英文名称: 1-(2-Pyrazinyl)-2-(2-pyridyl)-ethen
• 英文别名: 2-(β-(2-Pyridyl)-vinyl)-pyrazin；2-(2-pyridin-2-yl-vinyl)-pyrazine；2-[2-(Pyridin-2-yl)ethenyl]pyrazine；2-(2-pyridin-2-ylethenyl)pyrazine
• CAS: 66806-43-7
• 化学式: C₁₁H₉N₃
• 分子量: 183.213
• InChiKey: ULTVDQOYJMXUCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Anti-Angiogenic Compounds
  申请人：UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN

  公开号：US20160326122A1

  公开（公告）日：2016-11-10

  Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.

  描述了一些化合物和组合物，特别适用于治疗与血管生成相关的疾病或疾病，如眼部新血管生成、老年性黄斑变性、糖尿病性视网膜病变或癌症。
• [EN] ANTI-ANGIOGENIC COMPOUNDS<br/>[FR] COMPOSÉS ANTIANGIOGÉNIQUES
  申请人：UNIV DUBLIN

  公开号：WO2015107122A1

  公开（公告）日：2015-07-23

  Compounds of the formula A-X-Y-B and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age- related macular degeneration, diabetic retinopathy or cancer, wherein A is a six membered heteroaryl ring containing 2 nitrogen atoms which is optionally substituted with R1; R1 is H, CI-6 alkyl, CN, CONR2R3; R2 and R3 which may be the same or different and selected from H, CI-6 alkyl or R2 and R3 form a ring; the group X-Y is an alkyne or alkene, in the case wherein X-Y is an alkene the double bond may be cis or trans and optionally substituted with R1 B is an aryl; or five or six membered heteroaryl ring containing 1 to 3 heteroatoms, both of which may optionally substituted with one or more R4; R4 is R1 or OR5; R5 is H, COR6 or R6; and R6 is CI-6 alkyl and salts thereof.

  描述了化合物A-X-Y-B的结构式和组成物，这些化合物特别适用于治疗与血管生成相关的疾病或疾病，如眼部新血管生成、年龄相关性黄斑变性、糖尿病性视网膜病变或癌症，其中A是一个含有2个氮原子的六元杂环芳基环，可选择地取代为R1；R1为H、CI-6烷基、CN、CONR2R3；R2和R3可以相同也可以不同，选择自H、CI-6烷基或R2和R3形成环；X-Y是炔烃或烯烃，如果X-Y是烯烃，则双键可以为顺式或反式，并可选择地取代为R1；B是芳基；或含有1至3个杂原子的五元或六元杂环芳基环，两者均可选择地取代为一个或多个R4；R4为R1或OR5；R5为H、COR6或R6；R6为CI-6烷基及其盐。
• ANTI-ANGIOGENIC COMPOUNDS
  申请人：University College Dublin National University Of Ireland, Dublin

  公开号：EP3094625A1

  公开（公告）日：2016-11-23
• US9975860B2
  申请人：——

  公开号：US9975860B2

  公开（公告）日：2018-05-22