2-(2-氨基乙基)苯甲醛 | 343865-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-氨基乙基)苯甲醛
• 英文名称: 2-(2-aminoethyl)benzaldehyde
• CAS: 343865-17-8
• 化学式: C₉H₁₁NO
• 分子量: 149.192
• InChiKey: VZOJCPQBOMEFRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-氨基乙基)苯甲醛 在 magnesium sulfate 作用下， 以 二氯甲烷 、 对二甲苯 为溶剂， 反应 2.75h， 生成 rac-(1R,11bS)-1-hydroxy-2-isopropoxy-1,3-dimethyl-6,7-dihydro-1H-pyrido[2,1-a]isoquinolin-4(11bH)-one
  参考文献：
  名称：

  α-羟基环丁烯酮的四电子环开环/分子间[4 + 2]环加成：多种取代δ-内酰胺的立体选择性合成。

  摘要：

  报道了α-羟基环丁烯酮的四电子开环/分子间[4 + 2]环加成反应。该反应代表了广泛研究的烯醇-烯酮中间体的分子间环加成反应的第一个实例，并为在高立体选择性下取代取代的δ-内酰胺提供了一条新的合成途径。

  DOI：

  10.1002/adsc.201501152

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• REAGENTS AND METHODS FOR DIRECT LABELING OF NUCLEOTIDES
  申请人：MARKER GENE TECHNOLOGIES, INC.

  公开号：US20150152476A1

  公开（公告）日：2015-06-04

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活的重氮衍生物以用于标记核苷酸的系统和方法。标记核苷酸是通过将可检测基团的稳定肼基衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成的。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，因此所有类型的核苷酸都可以在不进行扩增或改变的情况下进行标记。
• O-, N- and carboxyl derivatives of thienamycin sulfoxide and sulfone, their preparation and pharmaceuticals containing said compounds
  申请人：Merck & Co., Inc.

  公开号：EP0001265A1

  公开（公告）日：1979-04-04

  Disclosed are O-, N- and substituted carboxyl derivatives of thienamycin sulfoxide (I, n =1) and thienamycin sulfone (I, n=2): wherein n is 1 or 2; R and R are independently selected from hydrogen and acyl; R is, interalia, hydrogen, acyl or alkyl; X is O or NR; and R is, inter alia, hydrogen or a pharmaceutically acceptable salt or ester moiety. Such derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.

  公开了噻吩霉素亚砜（I，n =1）和噻吩霉素砜（I，n =2）的 O-、N-和取代的羧基衍生物： 其中 n 为 1 或 2；R 和 R 独立选自氢和酰基；R 除其他外为氢、酰基或烷基；X 为 O 或 NR；R 除其他外为氢或药学上可接受的盐或酯分子。此类衍生物可用作抗生素。此外，还公开了制备此类衍生物的工艺、包含此类衍生物的药物组合物以及治疗方法，包括在需要抗生素效果时施用此类衍生物和组合物。
• Phosphorus-containing compound
  申请人：CHANG CHUN PLASTICS CO., LTD.

  公开号：US20040077825A1

  公开（公告）日：2004-04-22

  A phosphorus-containing compound represented by formula (I) and a preparation method thereof are provided. An addition reaction is performed for an organic cyclic phosphorus compound with an aryl aldehyde compound, and then a condensation reaction is performed with an aryl compound having active hydrogen in the use of an organic acid as a catalyst to obtain the proposed phosphorus-containing compound. This phosphorus-containing compound can be used as a hardener for resin, and improves flame retardant properties and thermal resistance for a flame retardant epoxy resin composition, thereby suitably applied to resin compositions used for manufacturing printed circuit boards and laminated circuit boards in electronic or electric products. 1

  本发明提供了一种由式（I）表示的含磷化合物及其制备方法。先将有机环状磷化合物与芳基醛化合物进行加成反应，然后在有机酸作为催化剂的情况下与具有活泼氢的芳基化合物进行缩合反应，从而得到拟议的含磷化合物。这种含磷化合物可用作树脂的固化剂，并可提高阻燃环氧树脂组合物的阻燃性能和耐热性，从而适用于电子或电气产品中用于制造印刷电路板和层压电路板的树脂组合物。 1
• Flame retarding resin composition
  申请人：——

  公开号：US20040077821A1

  公开（公告）日：2004-04-22

  Disclosed is a flame retarding resin composition comprising (A) one or more epoxy resins; (B) a hardener; and (C) a hardening accelerator, wherein the hardener of the component B is a phosphorus-containing compound represented by the following formula (I): 1 wherein each symbol is as defined below. The flame retarding resin composition of the present invention without adding halogen or other flame retardants has high flame retardancy and excellent heat resistance. The flame retarding resin composition of the present invention is suitably useful in the application of thermosetting resins, thermoplastic resins, bonding sheets, composite materials, laminated plates, printed circuit boards, copper foil adhesives, inks used for build-up process, semiconductor molding materials and the like.

  本发明公开了一种阻燃树脂组合物，该组合物包含(A)一种或多种环氧树脂；(B)一种固化剂；以及(C)一种硬化促进剂，其中成分 B 的固化剂是由下式(I)表示的含磷化合物： 1 其中各符号定义如下。本发明的阻燃树脂组合物不添加卤素或其他阻燃剂，具有高阻燃性和优异的耐热性。本发明的阻燃树脂组合物适用于热固性树脂、热塑性树脂、粘合片、复合材料、层压板、印刷电路板、铜箔粘合剂、用于堆积工艺的油墨、半导体成型材料等。