2-(2-溴苯基)吗啉 | 1097796-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 2-(2-溴苯基)吗啉
• 英文名称: 2-(2-Bromophenyl)morpholine
• CAS: 1097796-83-2
• 化学式: C₁₀H₁₂BrNO
• mdl: MFCD11646196
• 分子量: 242.11
• InChiKey: DYZGCDVZBPGIJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Alpha2C adrenoreceptor agonists
  申请人：McCormick D. Kevin

  公开号：US20080039439A1

  公开（公告）日：2008-02-14

  In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.

  在其许多实施方式中，本发明涉及一类新型的苯基吗啡啶和苯基硫代吗啡啶化合物，其可用作α2C肾上腺素能受体激动剂，含有该化合物的制药组合物，以及使用这些化合物或制药组合物治疗、预防、抑制或改善与α2C肾上腺素能受体激动剂相关的一种或多种疾病的方法。
• INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF
  申请人：Furuya Rikizou

  公开号：US20120059165A1

  公开（公告）日：2012-03-08

  A production method of an optically active 2-4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110° C. to 140° C. in a reaction mixture comprising a Na 2 CO 3 , an organophosphorus compound, and a palladium catalyst in a polar aprotic solvent alone or combination of a polar aprotic solvent and other polar aprotic solvent or hydrocarbon solvent to give a cyanophenylmorpholine; 2) reacting the cyanophenylmorpholine with hydroxylamine or hydroxylamine hydrochloride at a temperature of from 10° C. to 40° C. in an aprotic polar solvent to give a hydroxylamine derivative; 3) reacting the hydroxylamine derivative with an acylation reagent selected from the group consisting of aliphatic acyl halides, aromatic acyl halides, aliphatic acyl anhydrides and aromatic anhydrides; and 4) keeping the mixture obtained after step 3) at a temperature of from 60° C. to 140° C. to give a 2-4-(5-substituted-oxadiazolyl) phenyl}morpholine.

  提供了一种制备光学活性的2-4-(5-取代-噁唑基)苯基}吗啡啶的生产方法，该方法可用作合成药物的中间体，包括以下步骤1）至4）：1）在极性无水溶剂或极性无水溶剂和其他极性无水溶剂或碳氢溶剂的反应混合物中，以110℃至140℃的温度，使用Na2CO3、有机磷化合物和钯催化剂，将溴苯基吗啡与六氰合铁(II)或其水合物反应，得到氰苯基吗啡；2）在无水极性溶剂中，以10℃至40℃的温度，将氰苯基吗啡与羟胺或羟胺盐酸盐反应，得到羟胺衍生物；3）将羟胺衍生物与选自脂肪族酰卤、芳香族酰卤、脂肪族酰酐和芳香族酰酐的酰化试剂反应；4）将步骤3）得到的混合物保持在60℃至140℃的温度下，得到2-4-(5-取代-噁唑基)苯基}吗啡啶。
• CHROMENE COMPOUND AND CURABLE COMPOSITION
  申请人：Tokuyama Corporation

  公开号：EP2759543B1

  公开（公告）日：2017-07-19
• [EN] INTERMEDIATE COMPOUND FOR SYNTHESIZING PHARMACEUTICAL AGENT AND PRODUCTION METHOD THEREOF<br/>[FR] COMPOSÉ INTERMÉDIAIRE POUR SYNTHÉTISER UN AGENT PHARMACEUTIQUE ET SON PROCÉDÉ DE PRODUCTION
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2010104193A3

  公开（公告）日：2010-11-18
• 3,4-DIHYDR0-L,4-BENZ0XAZINE, 3, 4-DIHYDR0-1, 4-BENZOTHIAZINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS ALPHA2C ADRENORECEPTOR AGONISTS
  申请人：Schering Corporation

  公开号：EP2194986A1

  公开（公告）日：2010-06-16