(E)-2-[(3-cyclopentyloxy-4-methoxyphenyl)methylene]hydrazinoacetic acid | 312268-88-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-2-[(3-cyclopentyloxy-4-methoxyphenyl)methylene]hydrazinoacetic acid
• 英文别名: 2-[(2E)-2-[(3-cyclopentyloxy-4-methoxyphenyl)methylidene]hydrazinyl]acetic acid
• CAS: 312268-88-5
• 化学式: C₁₅H₂₀N₂O₄
• 分子量: 292.335
• InChiKey: SCSRTQOJASVWKH-CXUHLZMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  80.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl (E)-2-[3-cyclopentyloxy-4-methoxyphenylmethylene]hydrazinoacetate 、 sodium hydroxide 以 甲醇 为溶剂， 以to afford 0.75 g (70.77%) of white title solid的产率得到(E)-2-[(3-cyclopentyloxy-4-methoxyphenyl)methylene]hydrazinoacetic acid
  参考文献：
  名称：

  Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same

  摘要：

  本发明提供了式(I)的新型儿茶酚腙衍生物或其药学上可接受的盐，其中R1是C1-7烷基或C3-7环烷基；R2是氢、羟基、C1-5烷基或—CH2CH2C（═O）NH2；R3和R4独立地是氢、C1-7烷基、—C（═X）—R5，或2-、3-或4-吡啶基、嘧啶基或苯基，所述2-、3-或4-吡啶基、嘧啶基或苯基上选自卤素、C1-6烷氧基、硝基、三氟甲基、C1-6烷基和羧基的一种或两种取代基，或者R3和R4通过C3-4含氧、硫或氮的直接键合形成杂环环，X是氧、硫或NH，R5是C1-7烷基、—NHR6、CONH2或2-、3-或4-吡啶基、嘧啶基或苯基，所述2-、3-或4-吡啶基、嘧啶基或苯基上选自卤素、C1-6烷氧基、腈基、三氟甲基、C1-6烷基和羧基的一种取代基，R6是氢、羟基、NH2、C1-5烷氧基、C1-5烷基、吡啶基或苯基。

  公开号：

  US06610715B1

文献信息

• CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Cheil Jedang Corporation

  公开号：EP1187817A1

  公开（公告）日：2002-03-20
• US6610715B1
  申请人：——

  公开号：US6610715B1

  公开（公告）日：2003-08-26
• [EN] CATHECOL HYDRAZONE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME<br/>[FR] DERIVES DE CATHECOL-HYDRAZONE, PROCEDE DE PREPARATION CORRESPONDANT, ET COMPOSITION PHARMACEUTIQUE RENFERMANT LESDITS DERIVES
  申请人：CHEIL JEDANG CORP

  公开号：WO2000073280A1

  公开（公告）日：2000-12-07

  The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is C¿1-7? alkyl or C3-7 cycloalkyl; R?2¿ is hydrogen, hydroxy, C¿1-5? alkyl or -CH2CH2C(=O)NH2; R?3 and R4¿ are independently hydrogen, C¿1-7? alkyl, -C(=X)-R?5¿, or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one or two selected from a group consisting of halogen, C¿1-6? alkoxy, nitro, trifluoromethyl, C1-6 alkyl and carboxyl, or R?3 and R4¿ are directly bonded by C¿3-4? containing oxygen, sulfur or nitrogen to form a heterocyclic ring, X is oxygen, sulfur or NH and R?5¿ is C¿1-7? alkyl, -NHR?6¿, CONH¿2? or 2-, 3- or 4-pyridyl, prymidyl or phenyl substituted with one selected from a group consisting of halogen, C1-6 alkoxy, nitrile, trifluoromethyl, C1-6 alkyl and carboxyl, and R?6¿ is hydrogen, hydroxy, NH¿2?, C1-5 alkoxy, C1-5 alkyl, pyridyl or phenyl.