2-[[2-(3-carbamimidoylphenoxy)acetyl]amino]-N-[2-(1H-indol-3-yl)ethyl]acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[2-(3-carbamimidoylphenoxy)acetyl]amino]-N-[2-(1H-indol-3-yl)ethyl]acetamide
• 化学式: C₂₁H₂₃N₅O₃
• 分子量: 393.4
• InChiKey: PYPJVKIPSQFCOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  133
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• DIAMIDES WHICH INHIBIT TRYPTASE AND FACTOR XA ACTIVITY
  申请人：Morphochem Aktiengesellschaft Für Kombinatorische Chemie

  公开号：EP1370526A1

  公开（公告）日：2003-12-17
• Novel compounds that inhibit factor xa activity
  申请人：——

  公开号：US20040082547A1

  公开（公告）日：2004-04-29

  The present invention relates to compounds of the Formula 1 or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of Factor Xa and for the treatment and/or prevention of diseases that are mediated by Factor Xa activity.
• US7256194B2
  申请人：——

  公开号：US7256194B2

  公开（公告）日：2007-08-14
• [EN] DIAMIDES WHICH INHIBIT TRYPTASE AND FACTOR XA ACTIVITY<br/>[FR] DIAMIDES INHIBANT L'ACTIVITE DE LA TRYPTASE ET DU FACTEUR XA
  申请人：MORPHOCHEM AG KOMB CHEMIE

  公开号：WO2002068390A1

  公开（公告）日：2002-09-06

  The present invention relates do compounds of the Formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of Factor Xa and for the treatment and/or prevention of diseases that are mediated by Factor Xa activity.