Bisprezatide copper | 130120-56-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bisprezatide copper
• 英文别名: copper;(2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate
• CAS: 130120-56-8
• 化学式: C28H46CuN12O8
• 分子量: 742.3
• InChiKey: YINACRBQQGZRRM-XTQNZXNBSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -6.48
• 重原子数：
  49
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  358
• 氢给体数：
  10
• 氢受体数：
  14

文献信息

• Chemical derivatives of GHL-CU
  申请人：PROCYTE CORPORATION

  公开号：EP0288278A2

  公开（公告）日：1988-10-26

  Derivatives of GHL-Cu possessing greater resistance to proteolytic enzyme breakdown are disclosed. These deriva­tives can be tailored to increase their fat solubility, making them more useful in the formation of pharmaceutical creams and gels. Further, the derivatives of the present invention pos­sess significant superoxide dismustase activity, making them, useful for enhancing the wound-healing process in animals.

  本研究公开了具有更强抗蛋白水解酶分解能力的 GHL-Cu 衍生物。这些衍生物可以进行定制，以增加其脂溶性，使其更适用于制成药膏和凝胶。此外，本发明的衍生物具有显著的超氧化物歧化酶活性，可用于促进动物伤口愈合。
• Use of GHL-Cu as antiinflammatory agent
  申请人：PROCYTE CORPORATION

  公开号：EP0577151A1

  公开（公告）日：1994-01-05

  A compound containing glycyl-l-histidyl-l-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. The compound may be used to treat inflammatory conditions in animals and to reduce the traumatic effects in animals occurring subsequent to major tissue damage.

  本研究公开了一种含有甘氨酰-组氨酰-赖氨酸：铜（II）（GHL-Cu）的化合物。GHL-Cu 具有超氧化物歧化酶的功能，能解毒破坏组织的氧自由基，但不会引起抗原反应。该化合物可用于治疗动物的炎症，并减少动物在重大组织损伤后产生的创伤效应。
• Methods for the treatment of hyperpigmentation of skin
  申请人：ProCyte Corporation

  公开号：US20030134781A1

  公开（公告）日：2003-07-17

  Methods for treating hyperpigmentation of skin employ topical application of compositions to skin in need thereof, where the compositions comprise at least one peptide copper complex, or at least one peptide copper complex in combination with retinol, at least one retinol derivative, or a mixture thereof. Also disclosed are methods that use such compositions further comprising active agents selected from active drug substances, emollients, sunscreen agents, skin-lightening agents, skin protectants, skin conditioning agents, and humectants.

  治疗皮肤色素沉着的方法是在有需要的皮肤上局部施用组合物，其中组合物包含至少一种肽铜复合物，或至少一种肽铜复合物与视黄醇、至少一种视黄醇衍生物或它们的混合物的组合。还公开了使用这种组合物的方法，其中进一步包含选自活性药物物质、润肤剂、防晒剂、皮肤美白剂、皮肤保护剂、皮肤调理剂和保湿剂的活性剂。
• Skin care compositions containing peptide copper complexes and retinol, retinol derivatives, or a mixture thereof
  申请人：ProCyte Corporation

  公开号：US20030134780A1

  公开（公告）日：2003-07-17

  Compositions, generally useful for preserving the skin and/or improving its health and appearance, comprise a peptide copper complex and retinol, a retinol derivative, or a mixture thereof. In another embodiment, the disclosed compositions further comprise additives, including emollients, sunscreen agents, skin protectants, skin conditioning agents, and/or humectants. Also disclosed is a method for treating skin to accomplish such preservation and/or improvement thereof, where the method comprises the step of topically applying a disclosed composition to an area of skin in need of such treatment.

  通常用于保护皮肤和/或改善皮肤健康和外观的组合物包括肽铜复合物和视黄醇、视黄醇衍生物或其混合物。在另一个实施方案中，所公开的组合物进一步包含添加剂，包括润肤剂、防晒剂、皮肤保护剂、皮肤调理剂和/或保湿剂。还公开了一种治疗皮肤的方法，以达到上述保护和/或改善皮肤的目的，其中该方法包括将公开的组合物局部施用到需要治疗的皮肤区域的步骤。
• Stable solutions of peptide copper complexes and cosmetic and pharmaceutical formulations produced therefrom
  申请人：ProCyte Corporation

  公开号：US20030148927A1

  公开（公告）日：2003-08-07

  Compositions are formed by adding at least one amino acid to an aqueous solution of at least one peptide copper complex, and disclosed methods impart to solutions of peptide copper complexes, chemical stability and resistance to precipitation of the complexes through the addition of at least one of certain amino acids thereto. Also disclosed are compositions comprising at least one peptide copper complex and at least one of certain amino acids, as well as compositions further comprising one or more preservatives to provide thereto resistance to microbial attack and toxicity to microbes. Medical devices, pharmaceuticals and cosmetics comprising such compositions are also disclosed.

  通过向至少一种肽铜络合物的水溶液中添加至少一种氨基酸可形成组合物，所公开的方法通过向肽铜络合物的水溶液中添加至少一种特定氨基酸，可赋予络合物化学稳定性和抗沉淀性。此外，还公开了包含至少一种肽铜络合物和至少一种特定氨基酸的组合物，以及进一步包含一种或多种防腐剂的组合物，以提供抗微生物侵袭和抗微生物毒性的能力。此外，还公开了包含此类组合物的医疗器械、药品和化妆品。