BIM-26226

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: BIM-26226
• 英文别名: F5-D-Phe⁶-D-Ala¹¹-bombesin(6-13) methyl ester；H-D-Phe(F5)-Gln-Trp-Ala-Val-D-Ala-His-Leu-OMe；methyl (2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2R)-2-amino-3-(2,3,4,5,6-pentafluorophenyl)propanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoate
• 化学式: C₄₉H₆₃F₅N₁₂O₁₀
• 分子量: 1075.11
• InChiKey: ZCTCXFYZJYFGAQ-ZZXDJSGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  76
• 可旋转键数：
  28
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  344
• 氢给体数：
  11
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  在 三异丙基硅烷 、 水 、 三氟乙酸 、 苯酚 作用下， 反应 2.0h， 以77%的产率得到BIM-26226
  参考文献：
  名称：

  Rapid, Continuous Solution-Phase Peptide Synthesis:  Application to Peptides of Pharmaceutical Interest

  摘要：

  The Fmoc/TAEA and Bsmoc/TAEA methods for the rapid, continuous solution synthesis of peptide segments are shown to be applicable to the gram-scale synthesis of short peptides as well as, for the first time, to the synthesis of a relatively long (22-mer) segment, (hPTH 13-34). In the latter case the crude product was of significantly greater purity than a sample obtained via a solid-phase protocol. The Bsmoc methodology was optimized by a new technique involving filtration of the growing partially deprotected peptide at each coupling-deprotection cycle through a short column of silica gel.

  DOI：

  10.1021/op0202179

文献信息

• THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME
  申请人：Yamano Mayumi

  公开号：US20090093415A1

  公开（公告）日：2009-04-09

  [Problem]To provide a therapeutic agent for irritable bowel syndrome (IBS), which is excellent in efficacy and safety. [Means for Resolution]It was shown that the bombesin 2 (BB2) receptor antagonists typified by RC-3095 are therapeutic agents for irritable bowel syndrome (IBS), which show excellent efficacy in both of an abdominal symptom and bowel movement disorder. Thus, according to the present invention, it became possible to provide a therapeutic agent for irritable bowel syndrome (IBS) which comprises, as an active ingredient, a bombesin 2 (BB2) receptor antagonist exerting an excellent efficacy in both an abdominal symptom and bowel movement disorder.

  [问题] 提供一种治疗肠易激综合症（IBS）的治疗剂，其疗效和安全性均优秀。 [解决方法] 证明以RC-3095为代表的炸弹素2（BB2）受体拮抗剂是治疗肠易激综合症（IBS）的治疗剂，其在腹部症状和肠道运动障碍方面均表现出优异的疗效。因此，根据本发明，可以提供一种治疗肠易激综合症（IBS）的治疗剂，其包含作为活性成分的炸弹素2（BB2）受体拮抗剂，在腹部症状和肠道运动障碍方面表现出优异的疗效。
• US8101580B2
  申请人：——

  公开号：US8101580B2

  公开（公告）日：2012-01-24
• Rapid, Continuous Solution-Phase Peptide Synthesis:  Application to Peptides of Pharmaceutical Interest
  作者：Louis A. Carpino、Shahnaz Ghassemi、Dumitru Ionescu、Mohamed Ismail、Dean Sadat-Aalaee、George A. Truran、E. M. E. Mansour、Gary A. Siwruk、John S. Eynon、Barry Morgan

  DOI：10.1021/op0202179

  日期：2003.1.1

  The Fmoc/TAEA and Bsmoc/TAEA methods for the rapid, continuous solution synthesis of peptide segments are shown to be applicable to the gram-scale synthesis of short peptides as well as, for the first time, to the synthesis of a relatively long (22-mer) segment, (hPTH 13-34). In the latter case the crude product was of significantly greater purity than a sample obtained via a solid-phase protocol. The Bsmoc methodology was optimized by a new technique involving filtration of the growing partially deprotected peptide at each coupling-deprotection cycle through a short column of silica gel.