4-[N-(pyridin-3-yl)oxamoylamino-methyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[N-(pyridin-3-yl)oxamoylamino-methyl]benzoic acid
• 英文别名: 4-[[[2-Oxo-2-(pyridin-3-ylamino)acetyl]amino]methyl]benzoic acid
• 化学式: C₁₅H₁₃N₃O₄
• 分子量: 299.286
• InChiKey: FAHBENCYORXZFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Method of producing benzamide derivatives
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP0974576A2

  公开（公告）日：2000-01-26

  In the case that a selectively monoacylated phenylenediamine derivative of the following formula: wherein R1, R2, R3 and R10 have the meanings given in the description which is useful as any of medicines, agricultural chemicals, animal drugs and the intermediates of chemicals is prepared by reacting a benzoic acid derivative with a phenylenediamine derivative, the benzoic acid derivative is converted into a benzoyl imidazole derivative and this benzoyl imidazole derivative is then reacted with the phenylenediamine derivative, whereby the improvement of a preparation efficiency and the high selectivity of the monoacylation can be achieved, the steps of protection and deprotection being omitted.

  如果下式为选择性单乙酰化苯二胺衍生物： 其中 R1、R2、R3 和 R10 具有说明中给出的含义，该衍生物可用作药物、农药、动物用药和化学中间体中的任何一种，是通过苯甲酸衍生物与苯二胺衍生物反应制备的、将苯甲酸衍生物转化为苯甲酰基咪唑衍生物，然后将苯甲酰基咪唑衍生物与苯二胺衍生物反应，从而提高制备效率和单酰化的高选择性，省略保护和脱保护步骤。
• US6320078B1
  申请人：——

  公开号：US6320078B1

  公开（公告）日：2001-11-20