2-[Benzyl-(2-oxochromene-3-carbonyl)amino]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[Benzyl-(2-oxochromene-3-carbonyl)amino]acetic acid
• 化学式: C₁₉H₁₅NO₅
• 分子量: 337.3
• InChiKey: HQBUCFRKFLSDBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS DIRECTED AGAINST PILUS BIOGENESIS AND ACTIVITY IN PATHOGENIC BACTERIA; METHODS AND COMPOSITIONS FOR SYNTHESIS THEREOF<br/>[FR] COMPOSES DIRIGES CONTRE LA BIOGENESE ET L'ACTIVITE DU PILUS DE BACTERIES PATHOGENES, ET PROCEDES ET COMPOSITIONS DE SYNTHESE DESTINES A CES COMPOSES
  申请人：UNIV WASHINGTON

  公开号：WO2001020995A1

  公开（公告）日：2001-03-29

  Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.