2-(2-苯基-1,3-恶唑烷-3-基)乙醇 | 65017-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(2-苯基-1,3-恶唑烷-3-基)乙醇
• 英文名称: 2-phenyl-3-(β-hydroxyethyl)-1,3-oxazolidin
• 英文别名: 2-(2-phenyloxazolidin-3-yl)ethanol；2-(2-phenyl-oxazolidin-3-yl)-ethanol；2-(2-Phenyl-oxazolidin-3-yl)-aethanol；3-(2-hydroxyethyl)-2-phenyloxazolidine；3-<2-Hydroxy-ethyl>-2-phenyl-oxazolidin；3-(ss-Hydroxyethyl)-2,2-pentamethylen-oxazolidin；2-(2-phenyl-1,3-oxazolidin-3-yl)ethanol
• CAS: 65017-72-3；13657-17-5
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: SOXALKOOANKAEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-苯基-1,3-恶唑烷-3-基)乙醇 在 氯化亚砜 作用下， 生成 Benzylidene-bis-(2-chloro-ethyl)-ammonium; chloride
  参考文献：
  名称：

  Pettit, George R.; Rawson, Thomas E., Synthetic Communications, 1981, vol. 11, # 3, p. 179 - 184

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲醛 、 二乙醇胺 以80%的产率得到2-(2-苯基-1,3-恶唑烷-3-基)乙醇
  参考文献：
  名称：

  3-（β-羟乙基）-1,3-恶唑烷素的合成及抗菌性能

  摘要：

  3-（β羟基乙基）-1,3-恶唑烷和在位置其取代的衍生物的合成的可能性2检查由与某些醛和酮二乙醇胺的缩合heterocyclization。化合物的结构通过NMR光谱法鉴定。我们研究了合成化合物对影响润滑油M-11的微生物的抗微生物特性，并发现抗微生物特性对恶唑烷二杂环2位取代基性质的依赖性。

  DOI：

  10.1134/s1070427212010168

文献信息

• 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：US04080453A1

  公开（公告）日：1978-03-21

  1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

  1-取代-4-(1,2-二苯乙基)哌嗪衍生物的化学式为：##STR1## 其中X为2-或3-羟基，2-甲氧基，3-甲基，3-烷氧基（碳原子数为1至4），或2-或3-烷酰氧基（碳原子数为2至5）；R为烯丙基，3-羟基异戊基，3-甲基-2-丁烯基，3-甲基-3-丁烯基，丙基，未取代的含有5至8个碳原子的单环烷基，2-氯苯基，或被羟基或甲氧基取代的苯基；但当X为2位置的取代基时，R为环己基，当X为3-甲基时，R为2-甲氧基苯基或未取代的含有6至8个碳原子的单环烷基，以及其药学上可接受的盐，其制备方法，以及含有其作为基本活性成分的镇痛或止咳组合物。
• 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：US03957788A1

  公开（公告）日：1976-05-18

  1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##SPC1## Wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl, And their pharmaceutically acceptable salts, which have excellent analgesic, anti-tussive and anti-inflammatory activities, without undesirable side effect such as narcotic activity, and a process for the preparation thereof.

  公式为1-取代-4-(1,2-二苯乙基)哌嗪衍生物：##SPC1## 其中X为羟基、甲氧基、甲基或三氟甲基；R为未取代的含6到8个碳原子的单环烷基或2-甲氧基苯基；但当X为羟基时，R为环己基，当X为三氟甲基时，R为2-甲氧基苯基。它们的药物可接受盐具有出色的镇痛、镇咳和抗炎活性，没有如麻醉活性等不良副作用，并提供一种制备它们的方法。
• ONE-COMPONENT TYPE POLYURETHANE RESIN COMPOSITION FOR PREVENTING DETACHMENT OF CONCRETE PIECES AND TILES AND METHOD FOR PREVENTING DETACHMENT OF CONCRETE PIECES AND TILES USING SAME
  申请人：Dyflex Corporation

  公开号：US20130101744A1

  公开（公告）日：2013-04-25

  A one-component type polyurethane resin composition for preventing detachment of concrete pieces and tiles containing an isocyanate group-containing urethane prepolymer (A) and a thixotropy-imparting agent (B), and a method for forming a reinforcing layer on a surface of a concrete structure or tiled wall containing a resin coated film composed thereof, in order to provide a one-component type polyurethane resin composition for preventing detachment of concrete pieces and tiles, which has improved workability by being able to be applied with a trowel or brush, forms a transparent resin coated film after reactive curing that has improved weather resistance without applying a top coat, facilitates diagnosis of deterioration of concrete by being carried out visually during maintenance of concrete structures, is able to maintain the existing appearance of the tiled exteriors of buildings and other structures and eliminates dispersion to surrounding areas during application.

  一种单组分型聚氨酯树脂组合物，用于防止混凝土块和瓷砖的脱落，其中包含含有异氰酸基的聚氨酯预聚体（A）和增稠剂（B），以及一种在混凝土结构表面或瓷砖墙面形成加固层的方法，该方法包括使用由该组合物组成的树脂涂层膜，以提供一种单组分型聚氨酯树脂组合物，用于防止混凝土块和瓷砖的脱落，具有改善的可操作性，可以使用抹子或刷子施工，反应固化后形成透明的树脂涂层膜，具有改善的耐候性，无需施加面漆，可以在混凝土结构维护期间进行目视诊断混凝土的状况，能够保持建筑物和其他结构的瓷砖外观，施工时不会对周围环境造成扩散。
• One-package thixotropic polyurethane resin composition
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0965604A1

  公开（公告）日：1999-12-22

  A one-package thixotropic polyurethane resin composition comprising 10 to 90% by weight of a urethane prepolymer having a terminal free isocyanate group(a) which is obtained by reacting a polyisocyanate(b) with a compound having two or more active hydrogens(c), a monool(d) and an (N-hydroxyalkyl-oxazolidine compound(e), 0.1 to 20% by weight of hydrophobic fine powder silica(f) and 0.01 to 3.0% by weight of an oxazolidine-ring opening accelerator(g) is suitable for the use as a low modulus type sealant excellent in storage stability and curability and having low modulus and controlled foaming.

  一种单组分触变性聚氨酯树脂组合物，包括 10%至 90%（重量）具有末端游离异氰酸酯基团(a) 的聚氨酯预聚物，该聚氨酯预聚物是通过将多异氰酸酯(b)与具有两个或两个以上活性氢的化合物(c)、一元醇(d)和(N-羟基烷基-恶唑烷化合物(e))、0.1 至 20% (重量) 的疏水性粉末二氧化硅 (f) 和 0.01 至 3.0% (重量) 的噁唑烷开环促进剂 (g)，适用于作为一种低模量型密封剂使用，该密封剂具有优异的储存稳定性和固化性，模量低并可控制发泡。
• MONO-COMPONENT POLYURETHANE RESIN COMPOUND TO PREVENT PEELING OF CONCRETE SHEETS AND TILE AND PEELING PREVENTION METHOD FOR CONCRETE SHEETS AND TILES USING SAME
  申请人：Dyflex Corporation

  公开号：EP2578554A1

  公开（公告）日：2013-04-10

  The present invention provides a one-component type polyurethane resin composition for preventing detachment of concrete pieces and tiles containing an isocyanate group-containing urethane prepolymer (A) and a thixotropy-imparting agent (B), and a method for forming a reinforcing layer on a surface of a concrete structure or tiled wall containing a resin coated film composed thereof, in order to provide a one-component type polyurethane resin composition for preventing detachment of concrete pieces and tiles, which has superior workability by being able to be applied with a trowel or brush, forms a transparent resin coated film after reactive curing that has superior weather resistance without applying a top coat, facilitates diagnosis of deterioration of concrete by being carried out visually during maintenance of concrete structures, is able to maintain the existing appearance of the tiled exteriors of buildings and other structures and eliminates dispersion to surrounding areas during application, and a method for preventing detachment of concrete pieces and tiles that uses this composition.

  本发明提供了一种单组分型防止混凝土块和瓷砖脱落的聚氨酯树脂组合物，该组合物含有一种含异氰酸酯基的聚氨酯预聚物（A）和一种触变性引发剂（B），还提供了一种在含有由其构成的树脂涂膜的混凝土结构或瓷砖墙表面形成加固层的方法、该聚氨酯树脂组合物可以用抹子或刷子涂抹，具有优异的施工性，在反应性固化后形成透明的树脂涂膜，具有优异的耐候性，无需涂抹面漆，便于在维护混凝土结构时通过目视诊断混凝土的劣化情况，能够保持建筑物和其他结构的瓷砖外墙的现有外观，并且在涂抹过程中不会向周围扩散，还提供了一种使用该组合物的防止混凝土片和瓷砖脱落的方法。