2-Amino-6-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-6-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoic acid
• 化学式: C₁₂H₂₆N₆O₃
• 分子量: 302.37
• InChiKey: HOGMECWNPMOJQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  183
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Stable rgd peptidomimetic composition
  申请人：Massia P. Stephen

  公开号：US20060246104A1

  公开（公告）日：2006-11-02

  Disclosed herein are a chemical composition of 2-amino-6-[(2-amino-5guanidine}pentanoyl)amino]hexanoic acid (AAGPAHA) and a method of making it. The pharmaceutical composition includes AAGPAHA and a pharmaceutical excipient. Such a composition is used in cell attachment in culture, as a coating of biomaterials and implants. The pharmaceutical composition of AAGPAHA can be used to treat cancer, thrombosis, osteoporosis, retinopathy, renal insufficiency and wounds.

  本文披露了2-氨基-6-[(2-氨基-5鸟氨酸}戊酰)氨基]己酸（AAGPAHA）的化学组成及其制备方法。该制药组合物包括AAGPAHA和制药辅料。这样的组合物可用于细胞培养中的细胞附着，作为生物材料和植入物的涂层。 AAGPAHA的制药组合物可用于治疗癌症，血栓形成，骨质疏松症，视网膜病变，肾功能不全和伤口。
• [EN] STABLE RGD PEPTIDOMIMETIC COMPOSITION<br/>[FR] COMPOSITION PEPTIDOMIMETIQUE RGD STABLE
  申请人：UNIV ARIZONA

  公开号：WO2004094457A2

  公开（公告）日：2004-11-04

  Disclosed herein are a chemical composition of 2-amino-6-[(2-amino-5 guanidine}pentanoyl) amino] hexanoic acid (AAGPAHA) and a method of making it. The pharmaceutical composition includes AAGPAHA and a pharmaceutical excipient. Such a composition is used in cell attachment in culture, as a coating of biomaterials and implants. The pharmaceutical composition of AAGPAHA can be used to treat cancer, thrombosis, osteoporosis, retinopathy, renal insufficiency and wounds.