3-(3-Fluorophenoxy)-3-(3-fluorophenyl)-1-propylamine | 186495-87-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(3-Fluorophenoxy)-3-(3-fluorophenyl)-1-propylamine
• 英文别名: 3-(3-Fluorophenoxy)-3-(3-fluorophenyl)propan-1-amine
• CAS: 186495-87-4
• 化学式: C₁₅H₁₅F₂NO
• 分子量: 263.287
• InChiKey: FCMMUQIZOKQVDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods and compounds for treating depression and other disorders
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US20040039014A1

  公开（公告）日：2004-02-26

  The present invention features compounds active at both the serotonin reuptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor (“multi-active compounds”) can be used to treat different types of disorders such as depression, obsessive-compulsive disorders (OCD), sleep, disorders, sexual dysfunction, and eating disorders. Preferably, the multi-active compounds are used to treat depression.

  本发明的特点是活性化合物同时作用于5-羟色胺再摄取位点和N-甲基-D-天冬酰胺（NMDA）受体，并利用这些化合物治疗不同的疾病。在5-羟色胺再摄取位点和NMDA受体具有活性的化合物（“多活性化合物”）可用于治疗不同类型的疾病，如抑郁症、强迫症障碍（OCD）、睡眠障碍、性功能障碍和进食障碍。最好是，多活性化合物用于治疗抑郁症。
• METHODS AND COMPOUNDS FOR TREATING DEPRESSION
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1096926B1

  公开（公告）日：2007-02-28
• US7268166B2
  申请人：——

  公开号：US7268166B2

  公开（公告）日：2007-09-11
• [EN] METHODS AND COMPOUNDS FOR TREATING DEPRESSION AND OTHER DISORDERS<br/>[FR] PROCEDES ET COMPOSES PERMETTANT DE TRAITER LA DEPRESSION ET D'AUTRES TROUBLES
  申请人：NPS PHARMA INC

  公开号：WO2000002551A2

  公开（公告）日：2000-01-20

  The present invention features compounds active at both the serotonin euptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor ('multi-active compounds') can be used to treat different types of disorders such as depression, obsessive-compulsive disorders (OCD), sleep disorders, sexual dysfunction, and eating disorders. Preferably, the multi-active compounds are used to treat depression.