(2R)-N-acetyl-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-N-pyridin-4-ylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-N-acetyl-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-N-pyridin-4-ylpropanamide
• 化学式: C₁₄H₂₁N₅O₂S
• 分子量: 323.42
• InChiKey: ZLKXIBSFZGEQGF-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] NOVEL AMINO ACID HETEROCYCLIC AMIDE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] NOUVEAUX DERIVES AMIDE HETEROCYCLIQUES D'AMINOACIDES UTILISES COMME INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE
  申请人：SEARLE & CO

  公开号：WO2000026195A1

  公开（公告）日：2000-05-11

  Amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors, having formula (I) and pharmaceutically acceptable salts and prodrugs, wherein: J is O or S; B is NR5R11 wherein R11 is selected from a heterocyclic ring in which at least one member of the ring is carbon and in which 1 to about 4 heteroatoms are independently selected from oxygen, nitrogen and sulfur and said heterocyclic ring may be optionally substituted.