(6R)-N-hydroxy-6-hydroxy-6-[4-(3-phenoxyprop-1-ynyl)phenyl]hexanamide | 461405-70-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (6R)-N-hydroxy-6-hydroxy-6-[4-(3-phenoxyprop-1-ynyl)phenyl]hexanamide
• 英文别名: (6R)-N,6-dihydroxy-6-[4-(3-phenoxyprop-1-ynyl)phenyl]hexanamide
• CAS: 461405-70-9
• 化学式: C₂₁H₂₃NO₄
• 分子量: 353.418
• InChiKey: AIEUZRQRNZMTEZ-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Il-6 production inhibitors
  申请人：Naka Masao

  公开号：US20050119305A1

  公开（公告）日：2005-06-02

  An IL-6 production inhibitor which comprises a hydroxamic acid derivative of formula (I) (wherein all the symbols have the same meanings as defined in the specification), an equivalent thereof, a non-toxic salt thereof or a prodrug thereof as an active ingredient. Because of having an IL-6 production inhibitory activity, the compound of formula (I) may be useful for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, hypergammaglobulinemia (gammophathy), Castleman's disease, intra-atrial myxoma, diabetes, autoimmune disease, hepatitis, colitis, graft-versus-host disease, infectious diseases, endometriosis and solid cancer.

  一种IL-6产生抑制剂，包括式(I)的羟羟基酸衍生物（其中所有符号的含义与规范中定义的相同），其等效物，其非毒性盐或其前药作为活性成分。由于具有IL-6产生抑制活性，式(I)的化合物可能有助于预防和/或治疗各种炎症性疾病、败血症、多发性骨髓瘤、浆细胞白血病、骨质疏松症、消瘦症、牛皮癣、肾炎、肾细胞癌、卡波西肉瘤、类风湿性关节炎、高γ球蛋白血症（免疫球蛋白病）、卡斯尔曼病、心房内黏液瘤、糖尿病、自身免疫疾病、肝炎、结肠炎、移植物抗宿主病、传染病、子宫内膜异位症和实体癌症。