2-(3,5-二甲氧基-4-丙氧基苯基)乙胺 | 39201-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(3,5-二甲氧基-4-丙氧基苯基)乙胺
• 英文名称: 3,5-Dimethoxy-4-n-propyloxy-β-phenoaethylamin
• 英文别名: Proscaline；2-(3,5-dimethoxy-4-propoxyphenyl)ethanamine
• CAS: 39201-78-0
• 化学式: C₁₃H₂₁NO₃
• 分子量: 239.315
• InChiKey: HYWLMSUAZVDUFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基-4-羟基苯乙腈 在 palladium on activated charcoal 盐酸 、 氢气 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 2-(3,5-二甲氧基-4-丙氧基苯基)乙胺
  参考文献：
  名称：

  一系列4-取代的甲斯卡灵类似物的亲脂性和血清素激动剂活性。

  摘要：

  在绵羊脐动脉制剂中，用较高级的烷基同系物或溴代替甲斯卡林的4-甲氧基导致对5-羟色胺受体的活性增加。通过1-辛醇-水分配系数测得，该活性似乎与亲脂性相关，但是当4-取代基的长度约为5个原子时，该活性下降。建议采用3,4,5-三取代2,4,5-取代模式。

  DOI：

  10.1021/jm00212a022

文献信息

• [EN] PHENALKYLAMINES AND METHODS OF TREATING MOOD DISORDERS<br/>[FR] PHÉNALKYLAMINES ET PROCÉDÉS DE TRAITEMENT DE TROUBLES DE L'HUMEUR
  申请人：GILGAMESH PHARMACEUTICALS INC

  公开号：WO2022006186A1

  公开（公告）日：2022-01-06

  Phenalkylamines and methods of treating mood disorders with phenalkylamines. Also provided are pharmaceutical compositions that include phenalkylamines.

  Phenalkylamines和使用Phenalkylamines治疗情绪障碍的方法。还提供了包含Phenalkylamines的制药组合物。
• Methods of treating food allergy conditions
  申请人：Palo Alto Investors LP

  公开号：US11045454B2

  公开（公告）日：2021-06-29

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.

  本文提供了治疗食物过敏症的方法。这些方法的各个方面包括以有效治疗食物过敏症的方式向有需要的受试者施用迷幻剂。有效施用迷幻剂可包括以有效治疗受试者食物过敏症的量施用迷幻剂。在某些情况下，受试者已知患有食物过敏症。
• COMPOSITIONS COMPRISING A PSILOCYBIN DERIVATIVE AND A CANNABINOID
  申请人：CaaMTech, LLC

  公开号：US20190142851A1

  公开（公告）日：2019-05-16

  This disclosure pertains to new compositions and methods comprising a psilocybin derivative. In one embodiment, the compositions disclosed herein are used for a method of regulating a neurotransmitter receptor, e.g., a serotonin receptor. In one embodiment, the compositions disclosed herein comprise purified compounds, e.g., a purified psilocybin derivative, a purified cannabinoid, or purified terpene.
• Methods of Treating Food Allergy Conditions
  申请人：Palo Alto Investors LP

  公开号：US20200179349A1

  公开（公告）日：2020-06-11

  Methods for treating a subject for a food allergy condition are provided. Aspects of the methods include administering to a subject in need thereof a psychedelic agent in a manner effective to treat the subject for a food allergy condition. Effective administration of a psychedelic agent may include administering the psychedelic agent in an amount effective to treat the subject for the food allergy condition. In some instances, the subject is known to have a food allergy condition.
• TRYPTAMINE COMPOSITIONS FOR ENHANCING NEURITE OUTGROWTH
  申请人：STAMETS Paul Edward

  公开号：US20210069170A1

  公开（公告）日：2021-03-11

  Described herein are neurotrophic and nootropic compositions and methods for treating subjects with such compositions. In one aspect the composition comprises one or more tryptamines or in pure form or extracts from psilocybin containing mushrooms, or combinations thereof optionally combined with one or more phenethylamines or amphetamines in pure form or extracts from a plant or mushroom, or combinations thereof, optionally one or more erinacines or hericenones in pure form, extracts from Hericium mushroom species (e.g., H. erinaceus, H. coralloides, H. ramosum ) or combinations thereof, optionally one or more cannabinoids in pure form or extracts from Cannabis sativa, Cannabis sativa, Cannabis indica , or Cannabis ruderalis , optionally, one or more adversive compounds, and optionally one or more pharmaceutically acceptable excipients.