2-(3-吡啶基)乙硫醇 | 556825-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(3-吡啶基)乙硫醇
• 中文别名: 3-吡啶乙硫醇
• 英文名称: 3-(2-mercaptoethyl)pyridine
• 英文别名: 2-(3'-pyridyl)ethanethiol；3-pyridylethanethiol；2-(Pyridin-3-yl)ethane-1-thiol；2-pyridin-3-ylethanethiol
• CAS: 556825-56-0
• 化学式: C₇H₉NS
• 分子量: 139.221
• InChiKey: WQQJXTMFJYSLPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  13.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-nitrophenyl)methyl (6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 、 2-(3-吡啶基)乙硫醇 、 碘甲烷 生成 (6S)-6-[(1R)-1-hydroxyethyl]-3-[2-(1-methylpyridin-1-ium-3-yl)ethylsulfanyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  参考文献：
  名称：

  KIM, CHOUNG UN;MISCO, PETER F.;LUH, BING Y.;HITCHCOCK, MICHAEL J. M., J. ANTIBIOTICS, 40,(1987) N 12, 1707-1710

  摘要：

  DOI：
• 作为产物：
  描述：

  3-pyridylethyl thioacetate 在 lithium aluminium tetrahydride 、 水 、 溶剂黄146 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 、 乙酸乙酯 为溶剂， 反应 3.0h， 生成 2-(3-吡啶基)乙硫醇
  参考文献：
  名称：

  PROCESS FOR PREPARING BISPHENOL

  摘要：

  公开号：

  EP2390243B1

文献信息

• Novel compounds that are useful for improving pharmacokinetics
  申请人：Kempf J. Dale

  公开号：US20060199851A1

  公开（公告）日：2006-09-07

  Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.

  公式1的新化合物或其药用可接受的盐可以抑制细胞色素P450单加氧酶。
• 2-Substituted-1 H-benzimidazile-4-carboxamides are PARP inhibitors
  申请人：Zhu Gui-Dong

  公开号：US20060229351A1

  公开（公告）日：2006-10-12

  Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), method of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compound of Formula (I).

  公式（I）的化合物抑制PARP酶，可用于治疗与PARP相关的疾病或紊乱。还披露了包括公式（I）化合物的药物组合物、包括公式（I）化合物的治疗方法，以及包括公式（I）化合物的抑制PARP酶的方法。
• VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING
  申请人：Von Geldern Thomas W.

  公开号：US20090131379A1

  公开（公告）日：2009-05-21

  The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

  该发明涉及一种维生素D受体激活剂化合物，包括这种化合物的组合物，使用这种化合物和组合物的方法，制备这种化合物的过程，以及在这些过程中获得的中间体。
• Penem derivatives and antimicrobial agents containing the same
  申请人：SUNTORY LIMITED

  公开号：EP0774465A1

  公开（公告）日：1997-05-21

  Penem derivatives represented by the following Formula (I): wherein Z represents a hydroxyl group or a fluorine atom, R1 represents a substituted or unsubstituted alkyl, alkenyl, aralkyl group, aryl group, heterocyclic, or acyl group, or a hydrogen atom, and R2 represents a hydrogen atom or a carboxyl-protecting group; and pharmacologically acceptable salts thereof are antibacterial agents effective against, inter alia, methicillin-resistant Staphylococcus aureus. The derivatives and salts are novel except when R1 is ethyl and Z is hydroxyl. The analogous compounds in which R2 is a carboxyl-protecting group and any hydroxyl group represented by Z is protected are novel process intermediates.

  Penem衍生物由以下公式（I）表示：其中Z代表一个羟基团或氟原子，R1代表一个取代或未取代的烷基，烯基，芳基甲基，芳基，杂环基或酰基，或氢原子，R2代表一个氢原子或羧基保护基；及其药理学上可接受的盐是有效的抗菌剂，可用于治疗耐甲氧西林金黄色葡萄球菌等感染。这些衍生物和盐是新颖的，除非R1是乙基且Z是羟基。其中R2是羧基保护基且Z代表的任何羟基被保护的类似化合物是新颖的工艺中间体。
• METHODS FOR PREPARING CYCLOALKYLIDENE BISPHENOLS
  申请人：Kapila Debjani

  公开号：US20050137428A1

  公开（公告）日：2005-06-23

  A process for forming a cycloalkylidene bisphenol comprises: reacting a cycloalkanone compound of formula: where [A] is a substituted or an unsubstituted aromatic group, R 1 -R 4 independently represent a hydrogen or a C 1 -C 12 hydrocarbyl group; and “a” and “b” are integers independently having values from 0-3; with an aromatic hydroxy compound of formula [A]-OH, where [A] is as previously described; at a mole ratio of greater than or equal to about 20, in the presence of a sulfonic acid type ion exchange resin catalyst crosslinked with greater than or equal to about 8 weight percent of divinylbenzene, and a promoter selected from the group consisting of a mercaptan compound and a resorcinol compound; to form a cycloalkylidene bisphenol of formula: where [A], R 1 -R 4 , “a” and “b” are as previously described. Moreover, any acid catalyst can be used with a resorcinol promoter.

  形成环烷基亚苯酚的方法包括：将具有下列结构的环烷酮化合物与下列结构的芳香羟基化合物在摩尔比大于或等于约20的条件下反应，其中[A]是取代或未取代的芳香基团，R1-R4独立地代表氢或碳链长度为C1-C12的烃基团；“a”和“b”是整数，其值独立地取自0-3；在存在含有大于或等于约8重量百分比的二乙烯苯交联的磺酸型离子交换树脂催化剂和从巯基化合物和间苯二酚化合物中选择的促进剂组成的群体中，形成下列结构的环烷基亚苯酚：其中[A]，R1-R4，“a”和“b”如前所述。此外，任何酸催化剂均可与间苯二酚促进剂一起使用。