N²,N²'-bis(4-chlorophenyl)-N¹-cyclohexyl-1-phenylethane-1,2,2-tricarboxamide | 1428868-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N²,N²'-bis(4-chlorophenyl)-N¹-cyclohexyl-1-phenylethane-1,2,2-tricarboxamide
• 英文别名: 1-N,1-N-bis(4-chlorophenyl)-2-N-cyclohexyl-2-phenylethane-1,1,2-tricarboxamide
• CAS: 1428868-33-0
• 化学式: C₂₉H₂₉Cl₂N₃O₃
• 分子量: 538.474
• InChiKey: JBWQTCZWIWJYIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醛 在 copper(I) iodide 作用下， 以 乙醇 为溶剂， 反应 3.5h， 生成 N²,N²'-bis(4-chlorophenyl)-N¹-cyclohexyl-1-phenylethane-1,2,2-tricarboxamide
  参考文献：
  名称：

  Pseudo five-component process for the synthesis of functionalized tricarboxamides using CuI nanoparticles as reusable catalyst

  摘要：

  An efficient and multicomponent method has been developed for the synthesis of functionalized tricarboxamides at room temperature using CuI nanoparticles as catalyst. This method involved five-component coupling reactions of Meldrum's acid, isocyanides with aromatic aldehydes and amines at room temperature. Atom economy, wide range of products, excellent yields in short time and mild reaction conditions are some of the important features of this protocol. Notably, this catalyst could be recycled and reused for several times without significantly decreasing the catalytic activity. (C) 2013 Javad Safaei-Ghomi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.01.049

文献信息

• Pseudo five-component process for the synthesis of functionalized tricarboxamides using CuI nanoparticles as reusable catalyst
  作者：Abolfazl Ziarati、Javad Safaei-Ghomi、Sahar Rohani

  DOI：10.1016/j.cclet.2013.01.049

  日期：2013.3

  An efficient and multicomponent method has been developed for the synthesis of functionalized tricarboxamides at room temperature using CuI nanoparticles as catalyst. This method involved five-component coupling reactions of Meldrum's acid, isocyanides with aromatic aldehydes and amines at room temperature. Atom economy, wide range of products, excellent yields in short time and mild reaction conditions are some of the important features of this protocol. Notably, this catalyst could be recycled and reused for several times without significantly decreasing the catalytic activity. (C) 2013 Javad Safaei-Ghomi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.