5,6-di(4-chlorophenyl)-1,3-dimethyl-5,6-dihydropyrido[4,3-d]pyrimidine-2,4-dione | 1421267-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 5,6-di(4-chlorophenyl)-1,3-dimethyl-5,6-dihydropyrido[4,3-d]pyrimidine-2,4-dione
• 英文别名: 5,6-bis(4-chlorophenyl)-1,3-dimethyl-5H-pyrido[4,3-d]pyrimidine-2,4-dione
• CAS: 1421267-05-1
• 化学式: C₂₁H₁₇Cl₂N₃O₂
• 分子量: 414.291
• InChiKey: NWTYZEPWOGEUHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯-N-(4-氯苯亚甲基)苯胺 、 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以95%的产率得到5,6-di(4-chlorophenyl)-1,3-dimethyl-5,6-dihydropyrido[4,3-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Efficient synthesis of dihydropyrido[4,3-d]pyrimidines by microwave-promoted three-component aza-Diels–Alder reaction

  摘要：

  A microwave-promoted solvent- and catalyst-free aza-Diels-Alder reaction is described. 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil reacts with aldehyde and amine inside a microwave reactor to produce dihydropyrido[4,3-d]pyrimidine derivatives in excellent yield and within a yew short time. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.018

文献信息

• Efficient synthesis of dihydropyrido[4,3-d]pyrimidines by microwave-promoted three-component aza-Diels–Alder reaction
  作者：Manas M. Sarmah、Rupam Sarma、Dipak Prajapati、Wenhao Hu

  DOI：10.1016/j.tetlet.2012.11.018

  日期：2013.1

  A microwave-promoted solvent- and catalyst-free aza-Diels-Alder reaction is described. 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil reacts with aldehyde and amine inside a microwave reactor to produce dihydropyrido[4,3-d]pyrimidine derivatives in excellent yield and within a yew short time. (C) 2012 Elsevier Ltd. All rights reserved.