4-(vinyloxy)-benzonitrile | 34649-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(vinyloxy)-benzonitrile
• 英文别名: 4-cyanophenyl vinyl ether；para-vinyloxycyanobenzene；p-Cyanphenyl-vinyl-ether；4-Ethenoxybenzonitrile
• CAS: 34649-15-5
• 化学式: C₉H₇NO
• 分子量: 145.161
• InChiKey: NSBWRQSIQVZTAF-UHFFFAOYSA-N

物化性质

• 沸点：
  127-128 °C(Press: 18 Torr)
• 密度：
  1.0843 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(vinyloxy)-benzonitrile 在 过氧化氢苯甲酰 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以30%的产率得到4-cyanophenoxyoxirane
  参考文献：
  名称：

  Sone, Tomomichi; Isobe, Masakazu; Takabatake, Eigo, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 7, p. 1922 - 1924

  摘要：

  DOI：
• 作为产物：
  描述：

  在 双氧水 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 4-(vinyloxy)-benzonitrile
  参考文献：
  名称：

  β-Phenylselenoethanol, an Efficient Reagent for the One-Pot Synthesis of Aryl Vinyl Ethers

  摘要：

  在 Mitsunobu 条件下用苯酚处理 β-苯基硒乙醇，然后用 30% 过氧化氢进行氧化-消除反应，在一锅两步转化过程中生成了芳基乙烯基醚，收率高达 85-90%。

  DOI：

  10.3184/030823408x360355

文献信息

• Solid-phase synthesis of aryl vinyl ethers based on polystyrene-supported β-phenylselenoethanol
  作者：Jia-Li Zhang、Shou-Ri Sheng、Xue Liu、Shu-Ying Lin

  DOI：10.3184/030823409x447682

  日期：2009.5

  A novel facile solid-phase organic synthesis of aryl vinyl ethers by reaction of polystyrene-supported β-phenylselenoethanol with phenols under Mitsunobu conditions and subsequent oxidation-elimination with 30% hydrogen peroxide has been developed. The advantages of this method include straightforward operation, lack of odour, good yield and high purity of the products.

  通过在 Mitsunobu 条件下使聚苯乙烯支撑的 β-苯基硒乙醇与苯酚反应，然后用 30% 过氧化氢进行氧化-消除，开发出了一种新型简便的芳基乙烯基醚固相有机合成方法。这种方法的优点是操作简单、无异味、收率高、产品纯度高。
• Polymer-Supported β-Bromoethyl Selenide: An Efficient Reagent for the Synthesis of Aryl Vinyl Ethers
  作者：Shou-Ri Sheng、Xiao-Ling Liu、Xing-Cong Wang、Qin Xin、Cai-Sheng Song

  DOI：10.1055/s-2004-834874

  日期：——

  A simple and efficient procedure for the solid-phase synthesis of aryl vinyl ethers using polymer-supported β-bromoethyl selenide with traceless linker strategy is described.

  描述了一种使用聚合物负载的 β-溴乙基硒化物和无痕连接策略固相合成芳基乙烯基醚的简单有效的程序。
• Solid-Phase Organic Synthesis of Aryl Vinyl Ethers Using Sulfone-Linking Strategy
  作者：Lamei Yu、Ni Tang、Shouri Sheng、Rubing Chen、Xiaoling Liu、Mingzhong Cai

  DOI：10.1002/cjoc.201100451

  日期：2012.5

  A novel facile solid‐phase organic synthesis of aryl vinyl ethers by reaction of polystyrene‐supported 2‐phenylsulfonylethanol with phenols under Mitsunobu conditions and subsequent elimination reaction with DBU has been developed. The advantages of this method include straightforward operation, good yield and high purity of the products. Alternatively, a typical example of Suzuki coupling reaction

  通过在Mitsunobu条件下使聚苯乙烯负载的2-苯基磺酰基乙醇与苯酚反应并随后与DBU消除反应，开发了一种新颖的简便的固相有机合成芳基乙烯基醚的方法。该方法的优点包括操作简单，产率高和产物纯度高。另外，进一步将树脂上的Suzuki偶联反应的典型例子用于制备4-苯基苯基乙烯基醚以扩展该方法。
• HIGH-PURITY SODIUM P-STYRENESULFONATE WITH EXCELLENT HUE, METHOD FOR PRODUCING THE SAME, POLY (SODIUM P-STYRENESULFONATE) WITH EXCELLENT HUE USING THE SAME, AND DISPERSANT AND SYNTHETIC STARCH FOR CLOTHING FINISHING USING THE POLY ( SODIUM P-STYRENESULFONATE)
  申请人：TOSOH ORGANIC CHEMICAL CO., LTD.

  公开号：US20150246876A1

  公开（公告）日：2015-09-03

  Provided are high purity sodium p-styrenesulfonate with an excellent hue which is useful as a reactive emulsifier or dispersant for producing a polymer emulsion, or synthetic starch for clothing ironing and poly(sodium p-styrene-sulfonate) with an excellent hue using the same or sodium p-styrenesulfonate improved in fluidity while keeping good solubility. An aqueous p-β-bromoethylbenzenesulfonic acid solution and an aqueous sodium hydroxide solution are reacted under specific conditions to control the particle size, thereby obtaining sodium p-styrenesulfonate particles improved in a balance between fluidity and solubility, and further, impurities such as isomers are reduced, thereby obtaining high-purity sodium p-styrenesulfonate with an excellent hue.

  提供高纯度的对苯乙烯磺酸钠，具有优异的色泽，可用作反应性乳化剂或分散剂，用于生产聚合物乳液或合成淀粉用于衣物熨烫以及使用相同或改善流动性但保持良好溶解性的对苯乙烯磺酸钠制备优良色泽的聚(对苯乙烯磺酸钠)。在特定条件下，将水溶性的对β-溴乙基苯磺酸和氢氧化钠水溶液反应，以控制粒子大小，从而获得改善流动性和溶解性平衡的对苯乙烯磺酸钠颗粒，进一步减少异构体等杂质，从而获得具有优异色泽的高纯度对苯乙烯磺酸钠。
• Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
  申请人：Kuroita Takanobu

  公开号：US20100121048A1

  公开（公告）日：2010-05-13

  The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C 1-10 alkyl group optionally having substituent(s), a C 2-10 alkenyl group optionally having substituent(s), or a C 2-10 alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

  本发明涉及一种由式(I)表示的化合物：其中，环A是一种5或6成员的芳香杂环，可选地具有取代基；U、V和W分别独立地为C或N，但当U、V和W中的任何一个为N时，其他的应为C；Ra和Rb分别独立地为一个环状基团，可选地具有取代基；一个C1-10烷基，可选地具有取代基；一个C2-10烯基，可选地具有取代基；或一个C2-10炔基，可选地具有取代基；X是一条键或具有1到6个原子的主链间隔；Y是具有1到6个原子的主链间隔；Rc是一个含有杂原子作为构成原子的碳氢基团，可选地具有取代基；m和n分别独立地为1或2；环B可选地具有取代基，或其盐。本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压、高血压引起的各种器官损伤等的药物。