2-[(2-ethyl)phenylamino]pyridine | 227805-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2-ethyl)phenylamino]pyridine
• 英文别名: N-2-pyridyl-2-ethylaniline；N-(2-ethylphenyl)pyridin-2-amine
• CAS: 227805-83-6
• 化学式: C₁₃H₁₄N₂
• mdl: MFCD24389996
• 分子量: 198.268
• InChiKey: BTBDKDGNZZWUFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(2-ethyl)phenylamino]pyridine 、 四氯化钛 在 sodium hydride 作用下， 以 乙醚 、 甲苯 为溶剂， 生成 bis(2-(2-ethyl)phenylaminopyridinato) titanium dichloridecomplex
  参考文献：
  名称：

  双（烷基苯基氨基吡啶并）二氯化钛作为乙烯聚合催化剂

  摘要：

  衍生自2-（2-乙基苯胺基）-，2-（3,5-二甲基苯胺基）吡啶，2-（4-正丁基苯胺基）-和2-（2- t合成了丁基丁基苯胺基吡啶并通过光谱法对其进行了表征。在MAO作为助催化剂的存在下，这些络合物用于催化乙烯的聚合。研究了复杂结构对聚合行为的影响。本研究中使用的所有烷基苯基氨基吡啶并钛配合物比未取代的双（苯基氨基吡啶并）二氯化钛配合物具有更高的摩尔质量。相应地，与未取代的双（苯基氨基吡啶并）钛催化剂相比，活性较低，摩尔质量分布较宽。烷基苯基氨基吡啶基钛催化剂的流动行为可能是摩尔质量分布较宽的原因。

  DOI：

  10.1016/j.molcata.2007.10.029
• 作为产物：
  描述：

  2-溴吡啶 、 2-乙基苯胺 在 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 22.0h， 生成 2-[(2-ethyl)phenylamino]pyridine
  参考文献：
  名称：

  Efficient catalytic aryl amination of bromoarenes using 3-iminophosphine palladium(II) chloride

  摘要：

  While pursuing the development of new hydroamination catalysts, a 3-iminophosphine palladium(II) chloride complex [(3IP)PdCl2] was synthesized that has subsequently proven to be an effective precatalyst for the aryl amination of bromoarenes. This (3IP)PdCl2 complex has been utilized in the catalytic aryl amination of both bromobenzene and bromopyridine derivatives, specifically yielding excellent activity in coupling reactions involving bromobenzene, 4-bromotoluene, and 2-bromopyridine. Using a standard set of catalytic conditions, many alkyl and aryl amines have been investigated as coupling partners in the aryl amination of bromoarenes. In general, secondary alkyl amines and ortho-substituted anilines proved to be the best substrates for this reaction, commonly giving quantitative conversion to products, while primary amines and other anilines gave only poor to moderate results. Catalytic screening data, product yields, and full characterization of isolated products are included. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.08.027

文献信息

• Rhodium-Catalyzed Synthesis of 2-Methylindoles via C–N Bond Cleavage of <i>N</i>-Allylbenzimidazole
  作者：Pragati Biswal、Tanmayee Nanda、Namrata Prusty、Smruti Ranjan Mohanty、Ponneri C. Ravikumar

  DOI：10.1021/acs.joc.2c03048

  日期：2023.7.7

  A rhodium-catalyzed oxidative C–H/N–H dehydrogenative [3 + 2] annulation strategy has been reported between anilines and N-allylbenzimidazole for the synthesis of 2-methylindole scaffolds. An N-allylbenzimidazole has been used as a 2C synthon for the synthesis of indole, and more importantly, this transformation involves the cleavage of the thermodynamically stable C–N bond of allylamine. Detailed

  据报道，苯胺和N-烯丙基苯并咪唑之间存在铑催化的氧化 C-H/N-H 脱氢 [3 + 2] 成环策略，用于合成 2-甲基吲哚支架。N-烯丙基苯并咪唑已被用作合成吲哚的2C合成子，更重要的是，这种转化涉及烯丙胺热力学稳定的C-N键的断裂。详细的机理研究已经完成，并在 HRMS 中检测到了关键的中间体。这种转化通过 C(sp 2 )–H 烯丙基化级联和随后的分子内环化进行。
• 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME
  申请人：Japan Tobacco Inc.

  公开号：EP0970954A1

  公开（公告）日：2000-01-12

  3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 4, R3 and R4 independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.

  提供了3-哌啶基-4-氧代喹唑啉衍生物，由式(I)表示： 其中 R 代表氨基或环状氨基，如二苯并氮杂卓，它们各自被取代或未被取代的芳基、取代或未被取代的杂芳基或类似基团取代，n 是 1 至 4 的整数，R3 和 R4 独立地代表氢原子、低级烷基或类似基团，或其药学上可接受的盐。本发明的化合物（I）具有优异的 MTP 抑制活性。因此，这些化合物不仅能抑制导致动脉硬化疾病的低密度脂蛋白的形成，还能调节血液中的总胆固醇、胆固醇和脂蛋白（如低密度脂蛋白），并通过调节 MTP 活性来调节细胞脂质。它们还可用作高脂血症或动脉硬化疾病的新型预防或治疗药物。此外，它们还可用作胰腺炎、肥胖症、高胆固醇血症和高甘油三酯血症的治疗或预防药物。
• US6235730B1
  申请人：——

  公开号：US6235730B1

  公开（公告）日：2001-05-22
• Efficient catalytic aryl amination of bromoarenes using 3-iminophosphine palladium(II) chloride
  作者：Danielle C. Samblanet、Joseph A.R. Schmidt

  DOI：10.1016/j.jorganchem.2012.08.027

  日期：2012.12

  While pursuing the development of new hydroamination catalysts, a 3-iminophosphine palladium(II) chloride complex [(3IP)PdCl2] was synthesized that has subsequently proven to be an effective precatalyst for the aryl amination of bromoarenes. This (3IP)PdCl2 complex has been utilized in the catalytic aryl amination of both bromobenzene and bromopyridine derivatives, specifically yielding excellent activity in coupling reactions involving bromobenzene, 4-bromotoluene, and 2-bromopyridine. Using a standard set of catalytic conditions, many alkyl and aryl amines have been investigated as coupling partners in the aryl amination of bromoarenes. In general, secondary alkyl amines and ortho-substituted anilines proved to be the best substrates for this reaction, commonly giving quantitative conversion to products, while primary amines and other anilines gave only poor to moderate results. Catalytic screening data, product yields, and full characterization of isolated products are included. (C) 2012 Elsevier B.V. All rights reserved.
• Bis(alkylphenylaminopyridinato) titanium dichlorides as ethylene polymerization catalysts
  作者：Markku Talja、Mika Polamo、Markku Leskelä

  DOI：10.1016/j.molcata.2007.10.029

  日期：2008.2

  titanium complexes derived from 2-(2-ethylanilino)-, 2-(3,5-dimethylanilino)pyridine, 2-(4-n-butylanilino)- and 2-(2-t-butylanilino)pyridine were synthesized and characterized by spectroscopic methods. These complexes were used to catalyze the polymerization of ethylene in the presence of MAO as cocatalyst. The effect of the complex structures on the polymerization behavior was studied. All the alkylp

  衍生自2-（2-乙基苯胺基）-，2-（3,5-二甲基苯胺基）吡啶，2-（4-正丁基苯胺基）-和2-（2- t合成了丁基丁基苯胺基吡啶并通过光谱法对其进行了表征。在MAO作为助催化剂的存在下，这些络合物用于催化乙烯的聚合。研究了复杂结构对聚合行为的影响。本研究中使用的所有烷基苯基氨基吡啶并钛配合物比未取代的双（苯基氨基吡啶并）二氯化钛配合物具有更高的摩尔质量。相应地，与未取代的双（苯基氨基吡啶并）钛催化剂相比，活性较低，摩尔质量分布较宽。烷基苯基氨基吡啶基钛催化剂的流动行为可能是摩尔质量分布较宽的原因。