2-(3,6-Diphenyl-2,5-dihydropyridazin-4-yl)-1h-benzimidazole | 1083198-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(3,6-Diphenyl-2,5-dihydropyridazin-4-yl)-1h-benzimidazole
• 英文别名: 2-(3,6-diphenyl-1,4-dihydropyridazin-5-yl)-1H-benzimidazole
• CAS: 1083198-24-6
• 化学式: C₂₃H₁₈N₄
• 分子量: 350.423
• InChiKey: NLRSLLVHOAWANM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3,6-Diphenyl-2,5-dihydropyridazin-4-yl)-1h-benzimidazole 在 溶剂黄146 作用下， 反应 1.0h， 以95%的产率得到2-[(3,5-diphenylpyrazol-4-yl)methyl]-1H-benzimidazole
  参考文献：
  名称：

  Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles

  摘要：

  2-(3,6-Diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles undergo a previously unknown type of recyclization of the pyridazine ring to a pyrazole to give 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles. It is suggested that the mechanism of this conversion, which includes formation of a secondary enhydrazine group in the diazine ring and its subsequent contraction, occurs after the intramolecular formation and opening of a cyclopropane ring.

  DOI：

  10.1007/s10593-008-0108-3

文献信息

• Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles
  作者：I. B. Dzvinchuk、A. N. Chernega、M. O. Lozinskii、A. A. Tolmachev

  DOI：10.1007/s10593-008-0108-3

  日期：2008.6

  2-(3,6-Diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles undergo a previously unknown type of recyclization of the pyridazine ring to a pyrazole to give 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles. It is suggested that the mechanism of this conversion, which includes formation of a secondary enhydrazine group in the diazine ring and its subsequent contraction, occurs after the intramolecular formation and opening of a cyclopropane ring.