ethyl 4,4-diethoxy-2-phenylbutanoate | 93157-44-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 4,4-diethoxy-2-phenylbutanoate
• 英文别名: 4.4-Diaethoxy-2-phenyl-buttersaeure-aethylester；4.4-Diaethoxy-2-phenyl-buttersaeure-aethyletser
• CAS: 93157-44-9
• 化学式: C₁₆H₂₄O₄
• 分子量: 280.364
• InChiKey: MARYUPUZRSBAML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4,4-diethoxy-2-phenylbutanoate 在 氯仿 、 sodium sulfate 、 三氟乙酸 作用下， 以 氯仿 、 甲苯 为溶剂， 反应 2.0h， 生成 2-(2-Ethoxycarbonyl-2-phenyl-ethyl)-[1,3]oxazinane-3-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Nielsen, Thomas E.; Meldal, Morten, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3765 - 3773

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-1,1-二乙氧基乙烷 生成 ethyl 4,4-diethoxy-2-phenylbutanoate
  参考文献：
  名称：

  Salmon-Legagneur,F.; Poulain,G., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1963, vol. 256, p. 702 - 705

  摘要：

  DOI：

文献信息

• Exploration of the interrupted Fischer indolization reaction
  作者：Alex W. Schammel、Ben W. Boal、Liansuo Zu、Tehetena Mesganaw、Neil K. Garg

  DOI：10.1016/j.tet.2010.02.050

  日期：2010.6

  molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an interrupted Fischer indolization sequence. The method is convergent, mild, operationally simple, broad in scope, and can be used to access enantioenriched products. In addition, our approach is amenable to the synthesis of furoindoline

  已经开发了一种收敛方法来访问存在于大量生物活性分子中的稠合二氢吲哚环系统。该策略涉及肼与潜在醛的缩合，以通过中断的 Fischer 吲哚化序列最终提供含二氢吲哚的产物。该方法收敛、温和、操作简单、适用范围广，可用于获得对映体富集的产品。此外，我们的方法适用于呋喃二氢吲哚和吡咯烷二氢吲哚天然产物的合成，如 physovenine 和 debromoflustramine B 的简洁正式全合成所证明的那样。 该策略可能会合成更复杂的目标，如公社生物碱。
• An Ir-photoredox-catalyzed decarboxylative Michael addition of glyoxylic acid acetal as a formyl equivalent
  作者：Sheng Zhang、Zhoumei Tan、Haonan Zhang、Juanli Liu、Wentao Xu、Kun Xu

  DOI：10.1039/c7cc06252d

  日期：——

  decarboxylative conjugated addition of glyoxylic acid acetals with various Michael acceptors, including unsaturated amide, ester, aldehyde, ketone, and nitrile under irradiation. Vinyl pyridine and -aryl styrene are also suitable substrates. The reaction offers various types of acetal products, which are of synthetic significance as protected aldehydes.

  我们在本文中报道了在辐照下具有各种迈克尔受体（包括不饱和酰胺，酯，醛，酮和腈）的乙醛酸乙二醛的铱-光氧化还原催化的脱羧共轭共轭加成。乙烯基吡啶和α-芳基苯乙烯也是合适的底物。该反应提供了各种类型的缩醛产物，这些缩醛产物作为被保护的醛具有合成意义。
• Deconstructive Carboxylation of Activated Alkenes with Carbon Dioxide
  作者：Pan‐Feng Yuan、Zhao Yang、Shan‐Shan Zhang、Can‐Ming Zhu、Xiu‐Long Yang、Qing‐Yuan Meng

  DOI：10.1002/anie.202313030

  日期：2024.1.25

  A novel metal-free photochemical method for the deconstructive carboxylation of alkenes with CO2 is reported for the first time. The power of this strategy is demonstrated for the late-stage carboxylation of bioactive molecule derivatives and the synthesis of propionate nonsteroidal anti-inflammatory drugs.

  首次报道了一种用于烯烃与CO 2解构羧化的新型无金属光化学方法。该策略的威力在生物活性分子衍生物的后期羧化和丙酸酯非甾体抗炎药的合成中得到了证明。
• An Interrupted Fischer Indolization Approach toward Fused Indoline-Containing Natural Products
  作者：Ben W. Boal、Alex W. Schammel、Neil K. Garg

  DOI：10.1021/ol901383j

  日期：2009.8.6

  An efficient method to access the fused indoline ring system present in a multitude of bioactive molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an interrupted Fischer indolization sequence. Our studies show that the approach will likely be amenable to the synthesis of complex targets, such as the communesin natural products.
• Nielsen, Thomas E.; Meldal, Morten, Journal of Organic Chemistry, 2004, vol. 69, # 11, p. 3765 - 3773
  作者：Nielsen, Thomas E.、Meldal, Morten

  DOI：——

  日期：——