O-2-pyridyl N-phenylcarbamate | 75741-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-2-pyridyl N-phenylcarbamate
• 英文别名: 2-Pyridinyl phenylcarbamate；pyridin-2-yl N-phenylcarbamate
• CAS: 75741-95-6
• 化学式: C₁₂H₁₀N₂O₂
• 分子量: 214.224
• InChiKey: NMQVKCSSLPARTC-UHFFFAOYSA-N

物化性质

• 沸点：
  338.3±24.0 °C(Predicted)
• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O-2-pyridyl N-phenylcarbamate 在 水 、 氢气 作用下， 生成 苯胺
  参考文献：
  名称：

  Berner, Joachim, Zeitschrift fur Chemie, 1982, vol. 22, # 6, p. 221 - 222

  摘要：

  DOI：
• 作为产物：
  描述：

  异氰酸苯酯 、 2-羟基吡啶 在 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 以75%的产率得到O-2-pyridyl N-phenylcarbamate
  参考文献：
  名称：

  Synthetic Access to New Carbamate and Thiocarbamate Derivatives from Pyridinecarbaldehyde Oximes and Hydroxypyridines

  摘要：

  [image omitted] The synthesis of pyridine carbamate and thiocarbamate derivates is described. A series of oxime carbamate and thiocarbamate derivatives were synthesized by the addition of 2-, 3-, and 4-pyridinecarbaldehyde oximes to isocyanates and isothiocyanates. Furthermore, carbamate and thiocarbamate derivatives of pyridine were synthesized by the addition of 2-, 3-, and 4-hydroxy pyridine to isocyanates and isothiocyanates. Their structures were confirmed by both analytical and spectral data.

  DOI：

  10.1080/00397911.2010.490627

文献信息

• [EN] DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS<br/>[FR] DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE ET COMPOSÉS APPARENTÉS ET LEUR UTILISATION DANS LE TRAITEMENT D'ÉTATS MÉDICAUX
  申请人：LYCERA CORP

  公开号：WO2019200120A1

  公开（公告）日：2019-10-17

  The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.

  这项发明提供了二氢异喹啉-2(1H)-甲酰胺及相关化合物、药物组合物，以及它们在治疗医疗状况（如癌症）和抑制HPK1活性中的用途。
• [EN] ALTERNATE PROCESSES FOR THE PREPARATION OF OMECAMTIV MECARBIL<br/>[FR] NOUVEAUX PROCÉDÉS DESTINÉS À LA PRÉPARATION DE L'OMÉCAMTIV MÉCARBIL
  申请人：DR REDDY’S LABORATORIES LTD

  公开号：WO2021070124A1

  公开（公告）日：2021-04-15

  Aspects of the present application relate to process for the preparation of Omecamtiv mecarbil and salts thereof. Specific aspects relate to novel urea intermediate, preparative process thereof and its use in the preparation of Omecamtiv mecarbil and salts thereof. The improved process for the preparation of Omecamtiv mecarbil are industrially viable.

  本申请的方面涉及制备Omecamtiv mecarbil及其盐的过程。具体方面涉及新型尿素中间体，其制备过程及其在制备Omecamtiv mecarbil及其盐中的应用。改进的Omecamtiv mecarbil制备过程具有工业可行性。
• COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
  申请人：NOVO NORDISK A/S

  公开号：EP1458374A2

  公开（公告）日：2004-09-22
• DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
  申请人：GOSSAMER BIO SERVICES, INC.

  公开号：US20210139484A1

  公开（公告）日：2021-05-13

  The invention provides dihydroisoquinoline-2(1H)-carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting HPK1 activity.
• ALTERNATE PROCESSES FOR THE PREPARATION OF OMECAMTIV MECARBIL
  申请人：DR. REDDY'S LABORATORIES LIMITED

  公开号：US20220411374A1

  公开（公告）日：2022-12-29

  Aspects of the present application relate to process for the preparation of Omecamtiv mecarbil and salts thereof. Specific aspects relate to novel urea intermediate, preparative process thereof and its use in the preparation of Omecamtiv mecarbil and salts thereof. The improved process for the preparation of Omecamtiv mecarbil are industrially viable.