ethyl 2-(2-methoxy-4-methylphenoxy)acetate | 667399-57-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-(2-methoxy-4-methylphenoxy)acetate
• CAS: 667399-57-7
• 化学式: C₁₂H₁₆O₄
• mdl: MFCD04057785
• 分子量: 224.257
• InChiKey: DDMYOTMQBJMRNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-(2-methoxy-4-methylphenoxy)acetate 在 水 、 三溴化硼 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-(2-hydroxy-4-methylphenoxy)acetic acid
  参考文献：
  名称：

  [EN] COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  [FR] COMPOSÉS UTILES EN TANT QUE MODULATEURS DE TRPM8

  摘要：

  公开号：

  WO2012061698A9

文献信息

• About the selectivity and reactivity of active nickel electrodes in C–C coupling reactions
  作者：Sebastian B. Beil、Manuel Breiner、Lara Schulz、Aaron Schüll、Timo Müller、Dieter Schollmeyer、Alexander Bomm、Michael Holtkamp、Uwe Karst、Wolfgang Schade、Siegfried R. Waldvogel

  DOI：10.1039/d0ra02673e

  日期：——

  conditions, which is superior to the reported powerful molybdenum system. The reactivity for dehydrogenative coupling reactions of this novel active anode increases when the electrolyte is not stirred during electrolysis. Besides the aryl–aryl coupling, a dehydrogenative arylation reaction of benzylic nitriles was found while stirring the mixture providing quick access to synthetically useful building

  在高度稳定的质子介质（如 1,1,1,3,3,3-六氟异丙醇）中运行的活性阳极很少见。在这种独特的溶剂中，镍在恒定电流条件下形成非牺牲活性阳极，优于报道的强大钼系统。当电解期间不搅拌电解质时，这种新型活性阳极的脱氢偶联反应的反应性会增加。除了芳基-芳基偶联之外，在搅拌混合物的同时发现了苄基腈的脱氢芳基化反应，从而可以快速获得合成有用的结构单元。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Priest Chad

  公开号：US20130324557A1

  公开（公告）日：2013-12-05

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括作为TRPM8调节剂有用的化合物，例如公式（I）的化合物及其亚属和种类；含有这些化合物的个人产品；以及这些化合物和个人产品的使用，特别是增加或诱导化学感受，例如冷却或寒冷感受的使用。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10016418B2

  公开（公告）日：2018-07-10

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括可用作 TRPM8 调节剂的化合物，如式（I）化合物及其亚属和种化合物；含有这些化合物的个人用品；以及这些化合物和个人用品的用途，特别是增加或诱导化学麻醉感觉的用途，如冷却或冷感。
• Inhibitors of the Notch transcriptional activation complex and methods for use of the same
  申请人：UNIVERSITY OF MIAMI

  公开号：US10501413B2

  公开（公告）日：2019-12-10

  Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.

  本文公开了 Notch 转录激活复合物的抑制剂，以及将其用于治疗或预防癌症等疾病的方法。本文所述的抑制剂可包括式（I）化合物及其药学上可接受的盐类：式 (I)，其中取代基如所述。
• INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME
  申请人：SPYVEE Mark

  公开号：US20180086700A1

  公开（公告）日：2018-03-29

  Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.