1-(1-Pyrenyl)-2-propanon | 70644-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-(1-Pyrenyl)-2-propanon
• 英文别名: 1-Pyren-1-ylpropan-2-one
• CAS: 70644-22-3
• 化学式: C₁₉H₁₄O
• 分子量: 258.32
• InChiKey: MYDIQUQNXSFOHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (三甲基硅基)乙酸乙酯 、 1-(1-Pyrenyl)-2-propanon 生成
  参考文献：
  名称：

  Convenient synthesis of 9-methylbenzo[a]pyrene

  摘要：

  DOI：

  10.1021/jo01330a026
• 作为产物：
  描述：

  1-芘甲醛 以 水 、 丙酮 、 乙腈 为溶剂， 生成 1-(1-Pyrenyl)-2-propanon
  参考文献：
  名称：

  Convenient synthesis of 9-methylbenzo[a]pyrene

  摘要：

  DOI：

  10.1021/jo01330a026

文献信息

• A METHOD FOR PREPARATION OF REDUCIBLE DEGRADABLE HYPERBRANCHED POLYMERIC MICELLES
  申请人：JIANGNAN UNIVERSITY

  公开号：US20180360753A1

  公开（公告）日：2018-12-20

  Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.

  提供了一种可降解的可还原的高支化聚合物纳米胶束及其制备方法和应用。通过亲核加成机制聚合半胱氨酸和聚乙二醇二环氧丙烷，一步合成并获得了由半胱氨酸和聚乙二醇结构单元交替形成的高支化聚合物；然后，在透析过程中通过自组装形成了高支化纳米胶束。高支化聚合物链段包含三级胺和二硫键结构单元，具有pH和还原响应性，高支化三维腔结构赋予了纳米胶束携带药物的能力。
• AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF
  申请人：Shanghai Jiao Tong University

  公开号：US20150031644A1

  公开（公告）日：2015-01-29

  The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

  这项发明提供了作为癌症治疗药物有用的新型两性药物-药物共轭物，以及相关的组合物和方法。
• Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof
  申请人：Shanghai Jiao Tong University

  公开号：US10463743B2

  公开（公告）日：2019-11-05

  The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

  本发明提供了可用于癌症治疗的新型两亲性药物共轭物及其组合物和方法。
• Method for preparation of reducible degradable hyperbranched polymeric micelles
  申请人：JIANGNAN UNIVERSITY

  公开号：US10576038B2

  公开（公告）日：2020-03-03

  Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.

  本发明提供了一种可还原降解超支化聚合物纳米簇及其制备方法和应用。胱胺和聚乙二醇二缩水甘油醚通过亲核加成机制进行聚合，一步合成并获得由胱胺和聚乙二醇结构单元交替产生的超支化聚合物，然后在透析过程中通过自组装形成超支化纳米胶束。超支化聚合物链段含有三级氨基和二硫键结构单元，具有酸碱度和还原反应性，超支化的三维空腔结构赋予了纳米胶束载药能力。
• Method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles
  申请人：JIANGNAN UNIVERSITY

  公开号：US10933028B2

  公开（公告）日：2021-03-02

  The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

  本发明公开了一种pH/还原响应型聚氨基酸齐聚物纳米颗粒的制备方法，属于高分子合成和生物医用材料技术领域。在本发明中，脂肪族胺用于引发γ-苄基-L-谷氨酸-N-羧酸酐的开环聚合，得到的聚（γ-苄基-L-谷氨酸）与 L-赖氨酸反应生成齐聚物。半胱胺交联该齐聚物，纯化后生成对 pH 值/还原反应敏感的聚氨基酸齐聚物纳米粒子。这种纳米粒子对 pH 值有反应，并能抵抗非特异性蛋白质吸附。由于半胱胺含有二硫键，纳米粒子具有灵敏的还原反应性，可在癌症靶点负载抗癌药物，实现控释。