2,2-diphenylethyl acetoacetate | 314775-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-diphenylethyl acetoacetate
• 英文别名: Diphenylacetessigester；2,2-diphenylethyl 3-oxobutanoate
• CAS: 314775-53-6
• 化学式: C₁₈H₁₈O₃
• 分子量: 282.339
• InChiKey: BZOWXNPUHXXHPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-diphenylethyl acetoacetate 、 间硝基苯甲醛 、 尿素 在 ammonium chloride 作用下， 以 甲醇 为溶剂， 反应 3.5h， 以73%的产率得到2,2-diphenylethyl 6-methyl-4-(3-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  参考文献：
  名称：

  Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents

  摘要：

  An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH4Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels. (c) 2006 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.01.007
• 作为产物：
  描述：

  2,4-噁丁环二酮 、 2,2-二苯基乙醇 在 碳酸氢钠 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以100%的产率得到2,2-diphenylethyl acetoacetate
  参考文献：
  名称：

  EP1191021

  摘要：

  公开号：

文献信息

• Dihydropyridine derivatives
  申请人：AJINOMOTO CO. INC

  公开号：US20020147222A1

  公开（公告）日：2002-10-10

  Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: 1 analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

  提供具有选择性N型钙通道拮抗活性的化合物。以下式表示的二氢吡啶衍生物：1的类似物及其药用盐具有选择性抑制N型钙通道作用的活性，它们可用作与N型钙通道相关的各种疾病的治疗剂。
• DIHYDROPYRIDINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1191021A1

  公开（公告）日：2002-03-27

  Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

  提供了具有选择性 N 型钙通道拮抗活性的化合物。下式所代表的二氢吡啶衍生物： 其类似物及其药学上可接受的盐类具有选择性抑制 N 型钙通道作用的活性，可用作与 N 型钙通道有关的各种疾病的治疗剂。
• US7247645B2
  申请人：——

  公开号：US7247645B2

  公开（公告）日：2007-07-24