N-(2-Aminoethyl)cyclobutanecarboxamide | 953721-33-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Aminoethyl)cyclobutanecarboxamide
• CAS: 953721-33-0
• 化学式: C₇H₁₄N₂O
• mdl: MFCD09733872
• 分子量: 142.2
• InChiKey: DYKSSQRWGWLBNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS
  申请人：RAQUALIA PHARMA INC.

  公开号：US20150291582A1

  公开（公告）日：2015-10-15

  The present invention relates to pyrazolopyridine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及吡唑吡啶衍生物，其具有钠离子电压门控通道的阻滞活性，包括TTX-S通道，并且可用于治疗或预防涉及钠离子电压门控通道的疾病和疾病。本发明还涉及包括这些化合物的制药组合物以及在预防或治疗涉及钠离子电压门控通道的疾病中使用这些化合物和组合物的用途。
• SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR
  申请人：Amgen, Inc.

  公开号：EP1416933B8

  公开（公告）日：2008-04-23
• US6977264B2
  申请人：——

  公开号：US6977264B2

  公开（公告）日：2005-12-20
• US9944634B2
  申请人：——

  公开号：US9944634B2

  公开（公告）日：2018-04-17
• [EN] SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR<br/>[FR] PIPERIDINES SUBSTITUEES UTILISEES COMME MODULATEURS DU RECEPTEUR DE LA MELANOCORTINE
  申请人：AMGEM INC

  公开号：WO2003009847A1

  公开（公告）日：2003-02-06

  Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.