N,N-succinyl-glycine-methyl ester | 89937-73-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-succinyl-glycine-methyl ester
• 英文别名: N,N-Succinyl-glycin-methylester；Acetic acid, succinimido-, methyl ester；methyl 2-(2,5-dioxopyrrolidin-1-yl)acetate
• CAS: 89937-73-5
• 化学式: C₇H₉NO₄
• mdl: MFCD04277785
• 分子量: 171.153
• InChiKey: LVOGNTQDHSWJQX-UHFFFAOYSA-N

物化性质

• 熔点：
  94.5-95.5 °C
• 沸点：
  349.0±25.0 °C(Predicted)
• 密度：
  1.313±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N-succinyl-glycine-methyl ester 在 一水合肼 作用下， 生成 N-(3-hydrazinocarbonyl-propionyl)-glycine hydrazide
  参考文献：
  名称：

  Werbin; Spoerri, Journal of the American Chemical Society, 1947, vol. 69, p. 1682

  摘要：

  DOI：
• 作为产物：
  描述：

  (cis-3-methoxycarbonyl-acryloylamino)-acetic acid methyl ester 在 乙醇 、 sodium 、 镍 、 xylene 作用下， 生成 N,N-succinyl-glycine-methyl ester
  参考文献：
  名称：

  Werbin; Spoerri, Journal of the American Chemical Society, 1947, vol. 69, p. 1682

  摘要：

  DOI：

文献信息

• Synthesis and antimicrobial activities of N-substituted imides
  作者：Frederic Zentz、Alain Valla、Regis Le Guillou、Roger Labia、Anne-Gabrielle Mathot、Danielle Sirot

  DOI：10.1016/s0014-827x(02)01217-x

  日期：2002.4

  toluene. Most of N-substituted maleimides showed an interesting antimicrobial activity towards bacteria from the ATCC collection (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) but the MIC values for P. aeruginosa were always high (128 microg/ml). The imides with alkyl substituents showed higher activities than aromatic

  在我们关于新型抗菌剂的研究计划领域中，合成了一系列N-取代的酰亚胺。这些化合物是通过将酰胺基酸在乙酸酐/乙酸钠或六甲基二硅氮烷/溴化锌中的羟基芳族衍生物环化而获得的。羟基烷基马来酰亚胺是通过将相应的氨基醇与马来酸酐在沸腾的甲苯中缩合而直接制备的。大多数N-取代的马来酰亚胺对来自ATCC集合的细菌（金黄色葡萄球菌ATCC 25923，粪肠球菌ATCC 29212，大肠杆菌ATCC 25922和铜绿假单胞菌ATCC 27853）显示出有趣的抗菌活性，但铜绿假单胞菌的MIC值始终很高（ 128微克/毫升）。具有烷基取代基的酰亚胺显示出比​​MIC值在8-32 microg / ml范围内的芳族类似物更高的活性。相比之下，琥珀酰亚胺几乎没有活性。
• The synthesis of δ-succinamidolœvulic acid and related compounds
  作者：A. Neuberger、J. J. Scott

  DOI：10.1039/jr9540001820

  日期：——
• Dual phase drug release system
  申请人：PAPISOV I. Mikhail

  公开号：US20070190018A1

  公开（公告）日：2007-08-16

  The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight≦10 kDa; denotes direct of indirect attachment of M to linker L M ; and each occurrence of L M is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.
• DUAL PHASE DRUG RELEASE SYSTEM
  申请人：Papisov Mikhail I.

  公开号：US20110059010A1

  公开（公告）日：2011-03-10

  The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect attachment of M to linker L M ; and each occurrence of L M is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.
• US7790150B2
  申请人：——

  公开号：US7790150B2

  公开（公告）日：2010-09-07