bis(3-nitrophenyl) succinate | 130912-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: bis(3-nitrophenyl) succinate
• 英文别名: succinic acid bis-(3-nitro-phenyl ester)；Bernsteinsaeure-bis-(3-nitro-phenylester)；Bis-(3-nitro-phenyl)-succinat；Bis(3-nitrophenyl) butanedioate
• CAS: 130912-20-8
• 化学式: C₁₆H₁₂N₂O₈
• 分子量: 360.28
• InChiKey: YCPJEZCBIWVPEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (1S,3R,5R,6R,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5-(aminomethyl)-10,15,20,25,30-pentakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol 、 bis(3-nitrophenyl) succinate 生成 N,N'-bis[[(1S,3R,5R,6R,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-31,32,33,34,35,36,37,38,39,40,41,42-dodecahydroxy-10,15,20,25,30-pentakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontan-5-yl]methyl]butanediamide
  参考文献：
  名称：

  COATES, JOHN H.;EASTON, CHRISTOPHER J.;VAN, EYK STEPHEN J.;LINCOLN, STEPH+, J. CHEM. SOC. PT 1. PERKIN TRANS. PT 1,(1990) N, C. 2619-2620

  摘要：

  DOI：
• 作为产物：
  描述：

  间硝基苯酚 、 丁二酰氯 生成 bis(3-nitrophenyl) succinate
  参考文献：
  名称：

  Bischoff; von Hedenstroem, Chemische Berichte, 1902, vol. 35, p. 4082

  摘要：

  DOI：

文献信息

• A Versatile Synthesis of Linked Cyclodextrins
  作者：Christopher J. Easton、Steven J. van Eyk、Stephen F. Lincoln、Bruce L. May、John Papageorgiou、Michael L. Williams

  DOI：10.1071/c96168

  日期：——

  Reactions of amino-substituted cyclodextrins with bis(3-nitrophenyl) oxalate, malonate, succinate and glutarate, and with diphenyl carbonate, afford a range of linked cyclodextrins. These include α- and β-cyclodextrin dimers, joined by substitution at either C6 or C3, and asymmetric species with a β-cyclodextrin bonded to an a-cyclodextrin and a C3-substituted cyclodextrin attached to a C6-substituted moiety.

  氨基取代的环糊精与双（3-硝基苯基）草酸酯、丙二酸酯、琥珀酸酯和戊二酸酯以及碳酸二苯酯的反应生成了一系列的环糊精、 丙二酸二（3-硝基苯基）草酸盐、丙二酸二（3-硝基苯基 环糊精。其中包括 α- 和 β-环糊精二聚体、 环糊精二聚体，通过 C6 或 C3 取代连接，以及具有 β-环糊精与 a-环糊精结合，C3-取代的环糊精与 C6 环糊精与 C6 取代的分子相连。
• Derivatized oligonucleotides having improved uptake and other properties
  申请人：ISIS Pharmaceutical, Inc.

  公开号：US20020177150A1

  公开（公告）日：2002-11-28

  Linked nucleosides having at least one functionalized nucleoside that bears a substituent such as a steroid molecule, a reporter molecule, a non-aromatic lipophilic molecule, a reporter enzyme, a peptide, a protein, a water soluble vitamin, a lipid soluble vitamin, an RNA cleaving complex, a metal chelator, a porphyrin, an alkylator, a pyrene, a hybrid photonuclease/intercalator, or an aryl azide photo-crosslinking agent exhibit increased cellular uptake and other properties. The substituent can be attached at the 2′-position of the functionalized nucleoside via a linking group. If at least a portion of the remaining liked nucleosides are 2′-deoxy-2′-fluoro, 2′-O-methoxy, 2′-O-ethoxy, 2′-O-propoxy, 2′-O-aminoalkoxy or 2′-O-allyloxy nucleosides, the substituent can be attached via a linking group at any of the 3′ or the 5′ positions of the nucleoside or on the heterocyclic base of the nucleoside or on the inter-nucleotide linkage linking the nucleoside to an adjacent nucleoside.

  具有至少一个功能化核苷的连接核苷，其具有一种取代基，例如类固醇分子、报告分子、非芳香族亲脂分子、报告酶、肽、蛋白质、水溶性维生素、脂溶性维生素、RNA裂解复合物、金属螯合剂、卟啉、烷基化剂、芘、混合光核酶/插入剂或芳基叠氮化合物光交联剂，表现出增加的细胞摄取和其他特性。取代基可以通过连接基连接到功能化核苷的2'-位。如果其余连接的核苷至少部分为2'-脱氧-2'-氟、2'-O-甲氧基、2'-O-乙氧基、2'-O-丙氧基、2'-O-氨基烷氧基或2'-O-烯丙氧基核苷，则取代基可以通过连接基连接到核苷的3'或5'位置，或连接核苷的杂环碱基上，或连接相邻核苷的核苷酸间连接上。
• Coates, John H.; Easton, Christopher J.; Eyk, Stephen J. van, Journal of the Chemical Society. Perkin transactions I, 1990, # 9, p. 2619 - 2620
  作者：Coates, John H.、Easton, Christopher J.、Eyk, Stephen J. van、Lincoln, Stephen F.、May, Bruce L.、et al.

  DOI：——

  日期：——
• EP0431080A4
  申请人：——

  公开号：EP0431080A4

  公开（公告）日：1992-10-21
• COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND CHROMATOGRAPHY
  申请人：AUSTRALIAN COMMERCIAL RESEARCH & DEVELOPMENT LIMITED

  公开号：EP0431080A1

  公开（公告）日：1991-06-12