2-(4-四氢吡喃基氧基)苯胺 | 898289-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(4-四氢吡喃基氧基)苯胺
• 中文别名: 2-(四氢-2H-吡喃-4-氧基)苯胺
• 英文名称: 2-(tetrahydro-pyran-4-yloxy)-phenylamine
• 英文别名: 2-(Tetrahydropyran-4-yloxy)aniline；2-(oxan-4-yloxy)aniline
• CAS: 898289-35-5
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: CLGPZXHLRKSEDD-UHFFFAOYSA-N

物化性质

• 熔点：
  58-60.5

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

文献信息

• [EN] SUBSTITUTED PYRROLOPYRIMIDINES<br/>[FR] PYRROLOPYRIMIDINES SUBSTITUÉES
  申请人：BAYER PHARMA AG

  公开号：WO2013174743A1

  公开（公告）日：2013-11-28

  The present invention relates to substituted pyrrolopyrimidine compounds general formula I : in which A, X, R1, R2, m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式I的取代吡咯吡嘧啶化合物，其中A、X、R1、R2、m和n如本文所述和定义，以制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和配方，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防高增殖和/或血管生成障碍的疾病，作为唯一药剂或与其他活性成分组合使用。
• THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS
  申请人：Taylor Steven

  公开号：US20100143341A1

  公开（公告）日：2010-06-10

  The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

  本发明涉及通式（I）的新型药物组合物，其包括噻唑嘧啶化合物。此外，本发明涉及使用本发明的噻唑嘧啶化合物生产药物组合物，用于预防和/或治疗可以通过抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b）及/或其变体的激酶活性而受到影响的疾病。
• SUBSTITUTED PYRROLOPYRIMIDINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150133426A1

  公开（公告）日：2015-05-14

  The present invention relates to substituted pyrrolopyrimidine compounds general formula I: in which A, X, R 1 , R 2 , m and n are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及替代吡咯吡嘧啶化合物通式I：其中A、X、R1、R2、m和n如本文所述和定义的那样，以及制备所述化合物的方法，用于制备所述化合物的中间体化合物，包含所述化合物的制药组合物和组合物，以及用于制造治疗或预防疾病的制药组合物的使用，特别是治疗或预防增殖过度和/或血管生成障碍的疾病，作为唯一的治疗剂或与其他活性成分组合使用。
• [EN] THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS<br/>[FR] THIÉNOPYRIMIDINES POUR COMPOSITIONS PHARMACEUTIQUES
  申请人：DEVELOGEN AG

  公开号：WO2006136402A1

  公开（公告）日：2006-12-28

  [EN] The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
  [FR] L'invention concerne de nouvelles compositions pharmaceutiques de formule (I) renfermant des composés thiénopyrimidines. L'invention porte également sur l'utilisation des composés thiénopyrimidines précités dans la production de compositions pharmaceutiques destinées à la prophylaxie et/ou au traitement de maladies qui peuvent être influencées par l'inhibition de l'activité kinase de Mnk1 et/ou Mnk2 (Mnk2a ou Mnk2b) et/ou de variants de ces derniers.
• [EN] NOVEL USE OF THIENOPYRIMIDINES<br/>[FR] NOUVELLE UTILISATION DE THIÉNOPYRIMIDINES
  申请人：DEVELOGEN AG

  公开号：WO2007059905A2

  公开（公告）日：2007-05-31

  (EN) The present invention relates to the use of thienopyrimidine compounds for the production of pharmaceutical compositions for the treatment of inflammatory diseases.(FR) La présente invention concerne l’utilisation de composés de thiénopyrimidine pour la production de compositions pharmaceutiques pour le traitement de maladies inflammatoires.