N,N-diethyl-anthranilonitrile | 197507-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-anthranilonitrile
• 英文别名: N,N-Diaethyl-anthranilonitril；2-(diethylamino)benzonitrile
• CAS: 197507-52-1
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: YWJQYHVWROTJNW-UHFFFAOYSA-N

物化性质

• 沸点：
  289.1±23.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

SDS

2-(diethylamino)benzonitrileMSDS英文版

反应信息

• 作为产物：
  描述：

  碘乙烷 、 2-氨基苯甲腈 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以49%的产率得到N,N-diethyl-anthranilonitrile
  参考文献：
  名称：

  Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses

  摘要：

  本发明涉及N-(苄基)苯乙酰胺型多取代衍生物，包括含有该衍生物的药物组合物，以及其在人类和动物健康领域的治疗用途。本发明还涉及制备这些衍生物的方法。

  公开号：

  US20060079696A1

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS AS PDGFR KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUVANT ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DES KINASES PDGFR
  申请人：IRM LLC

  公开号：WO2013033620A1

  公开（公告）日：2013-03-07

  The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of PDGFR (PDGFRα, PDGFRβ) kinases or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.

  这项发明提供了化合物及其药物组合物，这些化合物可用作蛋白激酶抑制剂，以及使用这些化合物来治疗、改善或预防与异常或失调激酶活性相关的疾病的方法。在某些实施方式中，该发明提供了使用这些化合物来治疗、改善或预防涉及PDGFR（PDGFRα、PDGFRβ）激酶或c-kit和PDGFR（PDGFRα、PDGFRβ）激酶异常激活的疾病或紊乱的方法。
• Photocurable resin composition
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0136186A2

  公开（公告）日：1985-04-03

  A photocurable composition comprising (a) a radical-poly- merizabie monomer, (b) a -ketocarbonyl compound and (c) a derivative of mercaptobenzimidazole, mercaptobenzothiazole or mercaptobenzoxazole or an aromatic amine nucleus-substituted with an electron-attractive group has a high photocuring speed at near to normal temperature to give a cured product of excellent physical properties. This composition is valuable as a dental adhesive or resin.

  一种光固化组合物由以下部分组成：(a) 自由基聚梅里扎比单体；(b) 酮羰基化合物；(c) 巯基苯并咪唑、巯基苯并噻唑或巯基苯并恶唑的衍生物，或由引电子基团取代的芳香胺核。这种成分可用作牙科粘合剂或树脂。
• Adhesives for ceramics and processes for the bonding of ceramics using same
  申请人：MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0252603A2

  公开（公告）日：1988-01-13

  Adhesives for ceramics obtained as first adhesives for ceramics according to the invention are excellent in bond properties as well as in water resistance because they contain first acidic compounds such as organic carboxylic acids in addition to silane coupling agents, polymerizable monomers and polymerization catalysts. Further, adhesives for ceramics obtained as second adhesives for ceramics according to the invention are excellent in bond properties as well as in dependability and water resistance because they contain metal salts in addition to silane coupling agents, polymerizable monomers and polymerization catalysts. Furthermore, adhesives for ceramics obtained as third adhesives for ceramics according to the invention are excellent in bond properties as well as dependability and water resistance because they contain second acidic compounds selected from among metal salts and organic carboxylic acid anhydrides in addition to silane coupling agents, polymerizable monomers and polymerization catalysts.

  根据本发明作为陶瓷用第一粘合剂获得的陶瓷用粘合剂具有优异的粘合性能和耐水性，这是因为除了硅烷偶联剂、可聚合单体和聚合催化剂之外，它们还含有第一酸性化合物，如有机羧酸。此外，根据本发明作为陶瓷用第二粘合剂获得的陶瓷用粘合剂在粘合性能、可靠性和耐水性方面都非常出色，因为除了硅烷偶联剂、可聚合单体和聚合催化剂外，它们还含有金属盐。此外，根据本发明作为陶瓷用第三粘合剂获得的陶瓷用粘合剂在粘合性能、可靠性和耐水性方面都非常出色，因为它们除了含有硅烷偶联剂、可聚合单体和聚合催化剂外，还含有选自金属盐和有机羧酸酸酐的第二酸性化合物。
• Diene polymers and copolymers terminated by reaction with aromatic nitriles
  申请人：BRIDGESTONE/FIRESTONE, INC.

  公开号：EP0543128A1

  公开（公告）日：1993-05-26

  A terminally functionalized polymer is prepared by reacting a living polymer obtained by anionic polymerization of a diene monomer or mixture of a diene monomer and a vinyl aromatic hydrocarbon monomer with an aromatic nitrile compound. Especially useful aromatic nitriles are the unsubstituted and substituted benzonitriles. The resultant terminally functionalized polymers have reduced hysteresis in the carbon black reinforced and cured state and can be utilized to form elastomer compositions for tire treads having reduced rolling resistance.

  通过二烯单体或二烯单体与乙烯基芳香烃单体混合物的阴离子聚合反应得到的活聚合物与芳香族腈化合物发生反应，制备出端官能化聚合物。特别有用的芳香族腈是未取代的和取代的苯腈。由此得到的端基官能化聚合物在炭黑增强和固化状态下具有较低的滞后性，可用于形成弹性体组合物，用于降低滚动阻力的轮胎胎面。
• Diene polymeres and copolymers terminated with compounds having multiple-bonded nitrogen atoms and partially crosslinked with polyfunctional reagents
  申请人：BRIDGESTONE/FIRESTONE, INC.

  公开号：EP0639587A1

  公开（公告）日：1995-02-22

  Diene polymers or copolymers having improved raw polymer viscosity and reduced hysteresis in the cured and carbon black reinforced state are provided. These diene polymers or copolymers are prepared by a method which involves first terminating substantially all of the living diene polymer or copolymer chains obtained by anionic polymerization with a compound having multiple-bonded nitrogen atoms selected from the group consisting of aromatic nitriles and substituted imines having the formula and then coupling a portion of the resultant terminated polymer chains with a polyfunctional reagent selected from the groups consisting of silicon polyhalides, polyisocyanates, phosphoryl halides and polycarboxylic acid halides.

  本发明提供的二烯聚合物或共聚物在固化和炭黑增强状态下具有更高的原始聚合物粘度和更低的滞后性。这些二烯聚合物或共聚物的制备方法是：首先用一种具有多个键合氮原子的化合物将阴离子聚合得到的活的二烯聚合物或共聚物链基本上全部终止，该化合物选自芳香族腈和取代亚胺组成的组，其式为 然后将所得端接聚合物链的一部分与多官能试剂偶联，该多官能试剂选自由硅多卤化物、多异氰酸酯、磷酰卤化物和多羧酸卤化物组成的组。