5-phenoxy-2-propyl-valeric acid | 161089-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-phenoxy-2-propyl-valeric acid
• 英文别名: δ-Phenoxy-α-propyl-n-valeriansaeure；5-Phenoxy-2-propyl-valeriansaeure；5-phenoxy-2-propylpentanoic acid
• CAS: 161089-93-6
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: QZIZKLPKWLJVDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-phenoxy-2-propyl-valeric acid 在 乙醇 、 sodium 作用下， 生成 5-phenoxy-2-propyl-pentylamine
  参考文献：
  名称：

  Granger, Chemische Berichte, 1895, vol. 28, p. 1203

  摘要：

  DOI：
• 作为产物：
  描述：

  (3-phenoxy-propyl)-propyl-malonic acid 生成 5-phenoxy-2-propyl-valeric acid
  参考文献：
  名称：

  Granger, Chemische Berichte, 1895, vol. 28, p. 1203

  摘要：

  DOI：

文献信息

• NERVE REGENERATION PROMOTERS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1685832A1

  公开（公告）日：2006-08-02

  A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.

  由式 (I) 所表示的化合物组成的神经再生剂： (其中所有符号均在描述中显示）、其盐或其原药。本发明化合物可抑制神经细胞死亡，可作为加速干细胞（神经干细胞、胚胎干细胞、骨髓细胞等）生长和/或分化的物质、加速神经前体细胞生长和/或分化的物质、神经营养因子活性增效剂、神经营养因子样物质或神经退行性抑制剂，并通过新生、再生和/或轴突演化加速神经组织的修复和再生。此外，本发明的化合物可用于从脑组织、骨髓和/或胚胎干细胞中制备移植细胞（神经干细胞、神经前体细胞、神经细胞等），还可加速移植细胞的移植、生长、分化和/或功能表达，从而可用于预防和/或治疗神经退行性疾病。
• Pentanoic acid derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0632008B1

  公开（公告）日：1998-02-04
• Nerve regeneration promoters
  申请人：Tateishi Narito

  公开号：US20070043114A1

  公开（公告）日：2007-02-22

  A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and/or function expression of cells for transplant whereupon it is useful for prevention and/or treatment of neurodegenerative diseases.
• US6201021B1
  申请人：——

  公开号：US6201021B1

  公开（公告）日：2001-03-13
• US7176240B2
  申请人：——

  公开号：US7176240B2

  公开（公告）日：2007-02-13