N,N'-dimethylglutaramide | 56269-42-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N'-dimethylglutaramide
• 英文别名: N,N'-dimethyl-glutaramide；N,N'-Dimethyl-glutaramid；Glutarsaeure-bis-methylamid；N.N'-Dimethyl-glutarsaeure-diamid；N1,N5-Dimethylpentanediamide；N,N'-dimethylpentanediamide
• CAS: 56269-42-2
• 化学式: C₇H₁₄N₂O₂
• mdl: MFCD24390920
• 分子量: 158.2
• InChiKey: XRRGSVDOAOISSO-UHFFFAOYSA-N

物化性质

• 熔点：
  126 °C(Solv: benzene (71-43-2))
• 沸点：
  435.1±28.0 °C(Predicted)
• 密度：
  1.014±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-dimethylglutaramide 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N,N'-dimethylpentane-1,5-diamine
  参考文献：
  名称：

  158.一些潜在的细胞毒性甲基亚硝胺

  摘要：

  DOI：

  10.1039/jr9630000846
• 作为产物：
  描述：

  戊二腈 、 甲胺 在 水 作用下， 生成 N,N'-dimethylglutaramide
  参考文献：
  名称：

  Reactive Nitrile Groups. I. The Reaction of α,ι-Dinitriles with Aqueous Amines¹

  摘要：

  DOI：

  10.1021/ja01610a007

文献信息

• COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE
  申请人：Arvinas, Inc.

  公开号：US20180177750A1

  公开（公告）日：2018-06-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of enhancer of zeste homolog 2 (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为增强子锁定同源2的调节剂而发挥作用。具体而言，本公开涉及包含一端为Von Hippel-Lindau、cereblon、凋亡抑制蛋白或鼠双分子同源2配体的双功能化合物，该配体与相应的E3泛素连接酶结合，另一端含有结合目标蛋白的基团，使目标蛋白靠近泛素连接酶以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白的降解/抑制相关的广泛药理活性范围。本公开的化合物和组合物用于治疗或预防由目标蛋白聚集或积累导致的疾病或紊乱。
• Triazole antifungal agents
  申请人：Wu Nian

  公开号：US20100143455A1

  公开（公告）日：2010-06-10

  New triazole antifungal agents having C6S7 or S6C7 bridges are disclosed. These triazoles provide alternatives to existing antifungals in terms of formulation, bioavailability and activity.

  公开了具有C6S7或S6C7桥的新三唑类抗真菌药物。这些三唑类药物在配方、生物利用度和活性方面提供了替代现有抗真菌药物的选择。
• PHOTO-CROSSLINKER
  申请人：Kurdyumov Aleksey V.

  公开号：US20120149934A1

  公开（公告）日：2012-06-14

  Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.

  本文描述了一种连接剂，其中包括一个聚合物或非聚合物核心分子，以及通过尿素键、碳酸酯键或二者的组合而与核心分子共价连接的一个或多个光反应基团的连接元素。
• [EN] METHODS AND COMPOSITIONS FOR MODULATING SPLICING<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT DE MODULER L'ÉPISSAGEÉ
  申请人：SKYHAWK THERAPEUTICS INC

  公开号：WO2019028440A1

  公开（公告）日：2019-02-07

  Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

  本文描述了一种小分子剪接调节剂化合物，可调节由基因编码的mRNA（如pre-mRNA）的剪接，以及利用这些小分子剪接调节剂化合物调节剪接和治疗疾病和病况的方法。
• Method for the Preparation of Peptide-Oligonucleotide Conjugates
  申请人：Katzhendler Jehoshua

  公开号：US20080221303A1

  公开（公告）日：2008-09-11

  The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

  本发明涉及肽-寡核苷酸共轭物（POC）的合成。更具体地说，本发明涉及一种新颖的肽-寡核苷酸共轭物的制备方法，可以在固相支持下在温和条件下进行，可以手动或通过合成器进行，可以用于合成肽和寡核苷酸的交替序列，并适用于从交替肽和寡核苷酸块构建的各种肽-寡核苷酸共轭物的合成。