N-isopentyl-2-methylbut-3-en-2-amine | 960246-16-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-isopentyl-2-methylbut-3-en-2-amine
• 英文别名: 3-methyl-N-(2-methylbut-3-en-2-yl)butan-1-amine
• CAS: 960246-16-6
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: ZTVVKPUJGCPQHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊烯醇 在 4-二甲氨基吡啶 、 bis(η3-allyl-μ-chloropalladium(II)) 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 、 亚磷酸三乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 3-methyl-N-(3-methylbut-2-enyl)butan-1-amine 、 N-isopentyl-2-methylbut-3-en-2-amine
  参考文献：
  名称：

  Achieving Control over the Branched/Linear Selectivity in Palladium-Catalyzed Allylic Amination

  摘要：

  Palladium-catalyzed reaction of unsymmetrical allylic electrophiles with amines gives rise to regioisomeric allylic amines. We have found that linear products result from the thermodynamically controlled isomerization of the initially formed branched products. The isomerization is promoted by protic acid and active palladium catalyst. The use of base shuts down the isomerization pathway and allows for the preparation and isolation of branched allylic amines. Solvent plays a key role in achieving high kinetic regioselectivity and in controlling the rate of isomerization. The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocyclic allylic amines from their endocyclic precursors.

  DOI：

  10.1021/jo3025253

文献信息

• HYPERGLYCOSYLATED BINDING POLYPEPTIDES
  申请人：Genzyme Corporation

  公开号：EP3424956A1

  公开（公告）日：2019-01-09

  Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  提供了包含 CH1 结构域（例如人 IgG1 CH1 结构域）的结合多肽（例如抗体）及其效应分子共轭物，其中根据 Kabat 编号，CH1 结构域在氨基酸位置 114 有一个工程化的 N-连接糖基化位点。此外，还提供了编码抗原结合多肽的核酸、重组表达载体和用于制造这种抗原结合多肽的宿主细胞。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
• Chasing the Proton Culprit from Palladium-Catalyzed Allylic Amination
  作者：Igor Dubovyk、Iain D. G. Watson、Andrei K. Yudin

  DOI：10.1021/ja076659n

  日期：2007.11.1

  We have found that the addition of base has a significant effect on palladium-catalyzed allylic amination. The long-standing problem of controlling the branched-to-linear ratio has been solved. In the presence of DBU and inexpensive, readily available ligands, palladium-catalyzed allylation proceeds under kinetic control, leading to high branched selectivity. Given the widespread utility of palladium-catalyzed allylic amination, we expect that these findings will be relevant in many areas ranging from asymmetric catalysis to target-oriented synthesis.
• Achieving Control over the Branched/Linear Selectivity in Palladium-Catalyzed Allylic Amination
  作者：Igor Dubovyk、Iain D. G. Watson、Andrei K. Yudin

  DOI：10.1021/jo3025253

  日期：2013.2.15

  Palladium-catalyzed reaction of unsymmetrical allylic electrophiles with amines gives rise to regioisomeric allylic amines. We have found that linear products result from the thermodynamically controlled isomerization of the initially formed branched products. The isomerization is promoted by protic acid and active palladium catalyst. The use of base shuts down the isomerization pathway and allows for the preparation and isolation of branched allylic amines. Solvent plays a key role in achieving high kinetic regioselectivity and in controlling the rate of isomerization. The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocyclic allylic amines from their endocyclic precursors.