2,4-di-p-anisyl-6-methylpyrimidine | 99802-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-di-p-anisyl-6-methylpyrimidine
• 英文别名: 2,4-Bis(4-methoxyphenyl)-6-methylpyrimidine
• CAS: 99802-77-4
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.364
• InChiKey: IPVTVQAHAQZYRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-di-p-anisyl-6-methylpyrimidine 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 caesium carbonate 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 42.0h， 生成 {4-[2,6-Bis-(4-methoxy-phenyl)-pyrimidin-4-ylmethoxy]-2-methyl-phenoxy}-acetic acid methyl ester
  参考文献：
  名称：

  1,3,5-Trisubstituted aryls as highly selective PPARδ agonists

  摘要：

  A series of highly potent and selective PPAR delta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes lip to 10 mu M, making it a useful tool in studying the biological effects of selective PPAR delta activation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.079
• 作为产物：
  描述：

  2,4-二氯-6-甲基嘧啶 、 4-甲氧基苯硼酸 在 四(三苯基膦)钯 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 0.1h， 以80%的产率得到2,4-di-p-anisyl-6-methylpyrimidine
  参考文献：
  名称：

  1,3,5-Trisubstituted aryls as highly selective PPARδ agonists

  摘要：

  A series of highly potent and selective PPAR delta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes lip to 10 mu M, making it a useful tool in studying the biological effects of selective PPAR delta activation. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.079

文献信息

• Zielinski, Wojciech, Heterocycles, 1985, vol. 23, # 7, p. 1639 - 1644
  作者：Zielinski, Wojciech

  DOI：——

  日期：——
• Sandosham, Jessie; Undheim, Kjell; Rise, Frode, Heterocycles, 1993, vol. 35, # 1, p. 235 - 244
  作者：Sandosham, Jessie、Undheim, Kjell、Rise, Frode

  DOI：——

  日期：——
• 1,3,5-Trisubstituted aryls as highly selective PPARδ agonists
  作者：Robert Epple、Mihai Azimioara、Ross Russo、Badry Bursulaya、Shin-Shay Tian、Andrea Gerken、Maya Iskandar

  DOI：10.1016/j.bmcl.2006.02.079

  日期：2006.6

  A series of highly potent and selective PPAR delta agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes lip to 10 mu M, making it a useful tool in studying the biological effects of selective PPAR delta activation. (c) 2006 Elsevier Ltd. All rights reserved.