2-Isopropyl-1,3-oxazolidin | 27035-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 2-Isopropyl-1,3-oxazolidin
• 英文别名: 2-isopropyltetrahydro-1,3-oxazole；2-propan-2-yl-1,3-oxazolidine
• CAS: 27035-32-1
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: WGESJTHIONWBDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Isopropyl-1,3-oxazolidin 在 甲醇 、 palladium on activated charcoal 、 苯 作用下， 100.0 ℃ 、6.86 MPa 条件下， 生成 3-Isobutyl-2-isopropyl-1,3-oxazolidine
  参考文献：
  名称：

  Senkus, Journal of the American Chemical Society, 1945, vol. 67, p. 1517

  摘要：

  DOI：
• 作为产物：
  描述：

  C.I.酸性橙108 、 异丁醛 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 生成 2-Isopropyl-1,3-oxazolidin
  参考文献：
  名称：

  Oxazolidine derivatives

  摘要：

  新产品及其制备方法，主要是通过3-(环氧丙基)-1,3-噁唑烷及其衍生物与胺、醇、磺酸盐、巯基、叠氮化物或氰化物反应而得到的。此外，还包括含羧基的噁唑烷，其是通过将3-(环氧丙基)-1,3-噁唑烷与单或多羧酸反应而得到的。这些产品对于提高聚合物的粘附性和促进异氰酸酯和酸酐聚合物在室温下固化以制备新的塑料、粘合剂和涂料材料具有实用价值。

  公开号：

  US03937716A1

文献信息

• Anti-Viral Compounds
  申请人：DeGoey David A.

  公开号：US20100168138A1

  公开（公告）日：2010-07-01

  Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

  描述了一种有效抑制丙型肝炎病毒（“HCV”）复制的化合物。本发明还涉及制备这种化合物的方法、包含这种化合物的组合物，以及使用这种化合物治疗HCV感染的方法。
• 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
  申请人：VESTAS WIND SYSTEMS A/S

  公开号：US20140235620A1

  公开（公告）日：2014-08-21

  The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

  该发明涉及公式（I）的化合物或其药用盐，其中R1-R6在此处定义。该发明还涉及含有公式（I）化合物的组合物，以及利用这些化合物抑制具有新型活性的突变IDH蛋白。该发明还涉及利用公式（I）的化合物治疗与这些突变IDH蛋白相关的疾病或紊乱，包括但不限于细胞增殖紊乱，如癌症。
• Oxazolidine, oxazolidine-containing condensation and addition polymers
  申请人：Rohm and Haas Company

  公开号：US04002637A1

  公开（公告）日：1977-01-11

  The present invention is concerned with novel oxazolidines, polyoxazolidines, and particularly polymers of both condensation and addition type containing 1,3-oxazolidine groups linked to the polymer through an aliphatic ester linkage. They are the products of reaction between (1) 3-glycidyl-1,3-oxazolidines which may be substituted in the 2-position with an alkyl or aralkyl group and (2) a monocarboxylic acid, a polycarboxylic acid, or a polymer (of addition or condensation type) containing at least one carboxyl group. The polymeric products have improved adhesion when employed as adhesive or coating materials. The oxazolidine in such polymeric substances improves the usefulness of the polymers in regard to adhesiveness or cohesiveness when such polymers are used as coating compositions, adhesive compositions and for the molding of plastic articles. The non-polymeric products serve as intermediates which can be used as reactive components to react with carboxyl groups of addition or condensation polymers to introduce oxazolidine groups into such polymers to modify their adhesiveness. This application also covers methods of producing the new oxazolidine products and moisture-curable mixtures of a polyisocyanate and a reaction product of (1) and (2) above.

  本发明涉及新型噁唑烷、聚噁唑烷，尤其是含有1,3-噁唑烷基通过脂肪族酯键连接到聚合物上的缩合型和加成型聚合物。它们是由以下反应产生的产物：(1) 3-环氧基-1,3-噁唑烷，可以在2-位上用烷基或芳基烷基取代；(2) 单羧酸、多羧酸或至少含有一个羧基的聚合物（加成型或缩合型）。当作为粘合剂或涂料材料时，这些聚合物的粘附性得到了改善。这些聚合物物质中的噁唑烷增加了聚合物在涂料组合物、粘合组合物和塑料制品成型时的粘附性或内聚性的有用性。非聚合物产品可作为中间体，可用作与加成或缩合聚合物的羧基反应的反应组分，以将噁唑烷基引入这些聚合物中，从而改变它们的粘附性。本申请还涵盖了生产新型噁唑烷产品和含有（1）和（2）的反应产物的聚异氰酸酯和水固化混合物的方法。
• Substituted 2-arylimino heterocycles and compositions containing them for use as progesterone receptor binding agents
  申请人：——

  公开号：US20030207865A1

  公开（公告）日：2003-11-06

  This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

  本发明涉及2-芳基亚胺杂环，包括2-芳基亚胺-1,3-噻唑啉，2-芳基亚胺-2,3,4,5-四氢-1,3-噻嗪，2-芳基亚胺-1,3-噻唑啉-4-酮，2-芳基亚胺-1,3-噻唑啉-5-酮和2-芳基亚胺-1,3-噁唑啉，以及它们在调节孕激素受体介导的过程中的应用，以及用于这种治疗的制药组合物。
• Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
  申请人：Bayer Corporation

  公开号：US06353006B1

  公开（公告）日：2002-03-05

  This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

  本发明涉及2-芳基亚胺杂环，包括2-芳基亚胺-1,3-噻唑啉，2-芳基亚胺-2,3,4,5-四氢-1,3-噻嗪，2-芳基亚胺-1,3-噻唑啉-4-酮，2-芳基亚胺-1,3-噻唑啉-5-酮和2-芳基亚胺-1,3-噁唑啉，以及它们在调节孕激素受体介导的过程中的使用，以及用于这种治疗的药物组合物。