benzyl(2,3,5,6-tetrafluorophenyl)sulfane | 1376608-47-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: benzyl(2,3,5,6-tetrafluorophenyl)sulfane
• 英文别名: 3-Benzylsulfanyl-1,2,4,5-tetrafluorobenzene；3-benzylsulfanyl-1,2,4,5-tetrafluorobenzene
• CAS: 1376608-47-7
• 化学式: C₁₃H₈F₄S
• 分子量: 272.266
• InChiKey: CKCJNDIYEBXIEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  benzyl(2,3,5,6-tetrafluorophenyl)sulfane 在 三氯异氰尿酸 、 溶剂黄146 作用下， 以 水 、 乙腈 为溶剂， 反应 2.0h， 以80%的产率得到2,3,5,6-tetrafluorobenzenesulfonyl chloride
  参考文献：
  名称：

  [EN] 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS
  [FR] INHIBITEURS DE STAT3 DÉRIVÉS DE 2-ARYLSULFONAMIDO-N-ARYLACÉTAMIDE

  摘要：

  本公开提供了含有2-芳基磺酰胺基-N-芳基乙酰胺衍生的Stat3抑制剂及其某些药用盐的制药组合物，以及它们的使用方法。

  公开号：

  WO2018136935A1
• 作为产物：
  描述：

  硫代乙酸苄酯 、 五氟苯 在 potassium carbonate 、 L-脯氨酸 、 copper(I) bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以58%的产率得到benzyl(2,3,5,6-tetrafluorophenyl)sulfane
  参考文献：
  名称：

  Regioselective C–S bond formation accomplished by copper-catalyzed regioselective C–F substitution of perfluoroarenes with aryl thioacetates or benzyl thioacetate

  摘要：

  Practical and straightforward method for regioselective C-S bond formation accomplished by copper-catalyzed regioselective C-F substitution of electron-deficient perfluoroarenes with aryl thioacetates or benzyl thioacetate has been developed. Because of its high reaction efficiency, good chemoselectivity and regioselectivity, and excellent functional-group compatibility, this protocol provides a useful and operationally simple access to polyfluoroaryl thioethers used for drugs and material chemistry. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.091

文献信息

• Synthesis of polyfluorinated aromatic ethers and thioethers by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3
  作者：Cui-Cui Ma、Xing-Xing Zhu、Li Liu、Jian-Jun Dai、Jun Xu、Hua-Jian Xu

  DOI：10.1016/j.tetlet.2021.153387

  日期：2021.10

  A concise and efficient method for the synthesis of polyfluorinated aromatic ethers and thioethers by synergistic cleavage of C-B bond and C-F bond of B(C6F5)3 is reported. The reaction could proceed smoothly with excellent functional-group compatibility. In addition, the transformation represents the first general application of B(C6F5)3 as reaction partners in cross-coupling reaction.

  报道了一种通过协同裂解 B(C 6 F 5 ) 3的 CB 键和 CF 键合成多氟芳族醚和硫醚的简洁有效的方法。反应可以顺利进行，具有良好的官能团相容性。此外，该转变代表了 B(C 6 F 5 ) 3作为交叉偶联反应中的反应伙伴的首次普遍应用。
• [EN] 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS<br/>[FR] INHIBITEURS DE STAT3 DÉRIVÉS DE 2-ARYLSULFONAMIDO-N-ARYLACÉTAMIDE
  申请人：UNIV HAWAII

  公开号：WO2018136935A1

  公开（公告）日：2018-07-26

  The present disclosure provides pharmaceutical compositions comprising 2-arylsulfonamido-N-arylacetamide derivatized Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use.

  本公开提供了含有2-芳基磺酰胺基-N-芳基乙酰胺衍生的Stat3抑制剂及其某些药用盐的制药组合物，以及它们的使用方法。
• Regioselective C–S bond formation accomplished by copper-catalyzed regioselective C–F substitution of perfluoroarenes with aryl thioacetates or benzyl thioacetate
  作者：Qizhong Zhou、Bin Zhang、Tieqi Du、Haining Gu、Huajiang Jiang、Rener Chen

  DOI：10.1016/j.tet.2012.03.091

  日期：2012.6

  Practical and straightforward method for regioselective C-S bond formation accomplished by copper-catalyzed regioselective C-F substitution of electron-deficient perfluoroarenes with aryl thioacetates or benzyl thioacetate has been developed. Because of its high reaction efficiency, good chemoselectivity and regioselectivity, and excellent functional-group compatibility, this protocol provides a useful and operationally simple access to polyfluoroaryl thioethers used for drugs and material chemistry. (C) 2012 Elsevier Ltd. All rights reserved.