2-(butylthio)-4-methylthiazole | 5316-70-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-(butylthio)-4-methylthiazole
• 英文别名: 2-butylsulfanyl-4-methyl-thiazole；2-Butylmercapto-4-methyl-thiazol；2-butylthio-4-methylthiazol；2-Butylsulfanyl-4-methyl-1,3-thiazole
• CAS: 5316-70-1
• 化学式: C₈H₁₃NS₂
• 分子量: 187.33
• InChiKey: CEVFPTNWQRBBMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  硫氰酸丁酯 、 1-巯基-2-丙酮 在 哌啶 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 2-(butylthio)-4-methylthiazole
  参考文献：
  名称：

  Asinger,F. et al., Justus Liebigs Annalen der Chemie, 1975, p. 410 - 414

  摘要：

  DOI：

文献信息

• Dithiocarbamates as an efficient intermediate for the synthesis of 2-(alkylsulfanyl)thiazoles in water
  作者：Azim Ziyaei Halimehjani、Leila Hasani、M. Ali Alaei、Mohammad R. Saidi

  DOI：10.1016/j.tetlet.2016.01.045

  日期：2016.2

  A simple, green and high-yielding procedure for the synthesis of 4-substituted-2-(alkylsulfanyl)thiazoles from the reaction of dithiocarbamates and α-halocarbonyl containing compounds in water is described. Also, a one-pot, two-step procedure for the synthesis of 2-(alkylsulfanyl)thiazoles from acetophenone and dithiocarbamates was developed.

  描述了一种简单，绿色和高产率的方法，该方法可从二硫代氨基甲酸酯和含α-卤代羰基的化合物在水中反应合成4-取代的-2-（烷基硫烷基）噻唑。而且，开发了一种从一苯乙酮和二硫代氨基甲酸酯合成2-（烷基硫烷基）噻唑的一锅两步程序。
• N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
  申请人：Kurimura Muneaki

  公开号：US20090088406A1

  公开（公告）日：2009-04-02

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R 101 and R 102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物，其一般式为（1），或其盐，其中R101和R102分别是苯基或吡啶基，苯基或吡啶基可以具有一个或多个卤原子和低碳基团，可选地取代一个或多个卤原子等。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱并能够在短期内展现足够治疗效果的药物制剂。
• N-N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
  申请人：KURIMURA Muneaki

  公开号：US20120065162A1

  公开（公告）日：2012-03-15

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R 101 and R 102 are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了一种吡咯烷化合物通式（1）或其盐，其中R101和R102各自独立地为苯基或吡啶基，所述苯基或吡啶基可以具有一个或多个卤素原子和低碳基团中的一个或多个卤素原子等取代基。本发明的吡咯烷化合物或其盐可用于制备具有更广泛治疗谱并能够在短期内展现足够治疗效果的药物制剂。
• N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2407451A1

  公开（公告）日：2012-01-18

  The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R101 and R102 are each independently a phenyl group, which may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.

  本发明提供了通式（1）的吡咯烷化合物或其盐，其中 R101 和 R102 各自独立地为苯基，该苯基可具有一个或多个选自卤素原子和任选被一个或多个卤素原子取代的低级烷基等的取代基。本发明的吡咯烷化合物或其盐可用于生产具有更广治疗范围的药物制剂，并能在短期给药后显示出足够的治疗效果。
• Thiazolethiols and their Derivatives
  作者：John J. D'Amico

  DOI：10.1021/ja01097a029

  日期：1953.1