Antibiotic A-40926 B2 | 871088-55-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Antibiotic A-40926 B2
• 英文别名: (1S,2R,19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-6-carboxy-4,5-dihydroxy-3-(10-methylundecanoylamino)oxan-2-yl]oxy-5,32-dichloro-22-(dimethylamino)-2,26,31,44,49-pentahydroxy-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41(57),42,44,46(51),47,49,65-henicosaene-52-carboxylic acid
• CAS: 871088-55-0
• 化学式: C₈₄H₉₀Cl₂N₈O₂₉
• 分子量: 1746.5
• InChiKey: OJESFQPLDXJICV-FLAGIKDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  123
• 可旋转键数：
  18
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  569
• 氢给体数：
  20
• 氢受体数：
  30

文献信息

• DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL INFECTIONS
  申请人：Stogniew Martin

  公开号：US20090298749A1

  公开（公告）日：2009-12-03

  The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A 0 , A 1 , B 1 , B 2 , C 0 , C 1 , isoB 0 , and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.
• DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：US20170190744A1

  公开（公告）日：2017-07-06

  The invention provides methods for drying dalbavancin. The method includes providing wet dalbavancin that includes dalbavancin, water, and a solvent. The wet dalbavancin is dried at at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the water level of the wet dalbavancin is less than about 20% (w/w). Water is then added to the dalbavancin and the resulting wet dalbavancin is dried at least once more at a temperature of about 30° C. or less, at a vacuum pressure of about 50 mbar or less, until the solvent level of the dalbavancin is less than about 3.0% (w/w).