methyl (2E)-2-hepten-4-ynoate | 54922-59-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (2E)-2-hepten-4-ynoate
• 英文别名: trans-2-Hepten-4-in-saeuremethylester；Methyl trans-2-hepten-4-ynoate；methyl (E)-hept-2-en-4-ynoate
• CAS: 54922-59-7
• 化学式: C₈H₁₀O₂
• 分子量: 138.166
• InChiKey: JNHCPYPVZFVKBC-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-trimethylsilyloxy-2-pentyne 、 甲氧羰基亚甲基三苯基正膦 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 60.0h， 以87%的产率得到methyl (2E)-2-hepten-4-ynoate
  参考文献：
  名称：

  DMP-mediated one-pot oxidative olefination of silyl ethers

  摘要：

  Silyl ethers of arylic, allylic, propargylic and unactivated alcohols could be deprotected and oxidized with Dess-Martin periodinane, and the resulting aldehydes could be directly converted to the corresponding alpha,beta-unsaturated esters in one pot with stabilized phosphoranes. Good selectivities were achieved upon a variety of protecting groups of alcohol by using this method. Other advantages of the protocol included simplicity of operations and high efficiency, as well as good to excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.04.021

文献信息

• MEDICAL DEVICES INCORPORATING FUNCTIONAL ADHESIVES
  申请人：Covidien LP

  公开号：US20140303432A1

  公开（公告）日：2014-10-09

  A method for treating a wound or defect at a surgical target site using a minimally invasive surgical procedure is provided which includes utilizing a surgical access device such as a port or a catheter having a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having affinity for binding a cellular component of tissue cells located at the target site; contacting the surface of the access device with the tissue cells, wherein upon contact of the reactive members on the surface of the access device with the tissue cells, the reactive members are released from the surface of the access device and bind to the tissue; providing a tissue repair member having secured thereto a plurality of complementary reactive members of the specific binding pair; and applying the tissue repair member to the tissue, wherein upon contact of the complementary reactive members on the surface of the tissue repair member with the reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus bonding the tissue repair member to the tissue. A surgical access device for use in minimally invasive surgery is provided which includes a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having an affinity for binding a cellular component of tissue cells and another affinity for binding complementary members of the specific binding pair.
• US9272074B2
  申请人：——

  公开号：US9272074B2

  公开（公告）日：2016-03-01
• DMP-mediated one-pot oxidative olefination of silyl ethers
  作者：Guisheng Deng、Baihua Xu、Chunyu Liu

  DOI：10.1016/j.tet.2005.04.021

  日期：2005.6

  Silyl ethers of arylic, allylic, propargylic and unactivated alcohols could be deprotected and oxidized with Dess-Martin periodinane, and the resulting aldehydes could be directly converted to the corresponding alpha,beta-unsaturated esters in one pot with stabilized phosphoranes. Good selectivities were achieved upon a variety of protecting groups of alcohol by using this method. Other advantages of the protocol included simplicity of operations and high efficiency, as well as good to excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.