2-(4-硝基苯氧基)苯酚 | 39138-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-硝基苯氧基)苯酚
• 英文名称: 2'-hydroxy-4-nitrodiphenylether
• 英文别名: 2-(4-nitrophenoxy)phenol；(4-Nitro-phenyl)-(2-hydroxy-phenyl)-aether；O-(4-Nitro-phenyl)-brenzcatechin；2-Hydroxy-1-(4-nitro-phenoxy)-benzol；2-(4-Nitro-phenoxy)-phenol；o-(p-nitrophenoxy)phenol
• CAS: 39138-90-4
• 化学式: C₁₂H₉NO₄
• 分子量: 231.208
• InChiKey: DWENVBLWYBNNSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2909500000

反应信息

• 作为反应物：
  描述：

  2-(4-硝基苯氧基)苯酚 在 磺酰氯 作用下， 生成 4-chloro-2-(4-nitro-phenoxy)-phenol
  参考文献：
  名称：

  151.取代为2-甲氧基-硝基二苯醚

  摘要：

  DOI：

  10.1039/jr9340000705
• 作为产物：
  描述：

  C₁₂H₁₁NO₄ 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 为溶剂， 反应 8.0h， 以78%的产率得到2-(4-硝基苯氧基)苯酚
  参考文献：
  名称：

  Metal-free oxidative aromatization of 2-aryloxycyclohex-2-en-1-ones to 2-aryloxyphenols using DDQ/Amberlyst-15

  摘要：

  Efficient metal-free oxidative aromatization of 2-aryloxycyclohex-2-en-1-ones was achieved by a combination of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and Amberlyst-15. The conditions for oxidative aromatization are mild and applicable for a variety of substrates, and Amberlyst-15 can be successfully recovered and recycled.

  DOI：

  10.1134/s1070428014090115

文献信息

• Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
  申请人：——

  公开号：US20040209886A1

  公开（公告）日：2004-10-21

  Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.

  揭示了吡咯吡啶并嗪化合物，制备这类化合物的方法，以及它们用于治疗增殖性、炎症性和其他疾病的用途。
• Cyclodienones. X. Reaction of Halo-cyclohexadien-1-ones with Phenols in the Presence of α-Picoline and Preparation of 4-Hydroxy- and 2-Hydroxyphenyl Aryl Ethers
  作者：Masashi Tashiro、Takashi Itoh、Gouki Fukata

  DOI：10.1246/bcsj.57.416

  日期：1984.2

  Reaction of 4-halocyclohexadienones such as 4-bromo-(1a), 4-chloro-2,4,6-tri-t-butyl-(1b), 2,4-dichloro-4,6-di-t-butyl-2,5-cyclohexadien-1-one, and 2,4-dichloro-2,6-di-t-butyl-3,5-cyclohexadien-1-one with phenols in the presence of α-picoline was carried out under various conditions. The reaction of 1a and 1b with phenols afforded the corresponding 2-aryloxy-4,6-di-t-butyl phenols together with various

  4-卤代环己二烯酮如4-溴-(1a)、4-氯-2,4,6-三叔丁基-(1b)、2,4-二氯-4,6-二叔丁基的反应-2,5-环己二烯-1-酮和2,4-二氯-2,6-二叔丁基-3,5-环己二烯-1-酮在α-甲基吡啶存在下与苯酚进行各种条件。1a 和 1b 与苯酚反应得到相应的 2-芳氧基-4,6-二叔丁基苯酚以及各种副产物。由上述反应得到的 2-芳氧基-4,6-二-叔丁基-苯酚在 AlCl3 催化下发生叔丁基转移反应，得到相应的 2-羟基苯基芳基醚。4-芳氧基-2,4,6-三叔丁基-2,5-环己二烯-1-酮的类似反应也得到相应的4-羟基苯基芳基醚。
• Phenoxenium ions identical intermediates in the acid-catalyzed solvolysis of n-tosyl-O-Arylhydroxylamines and in the thermolysis of N-Aryloxypyridinium salts
  作者：Hiroyuki Iijima、Yasuyuki Endo、Koichi Shudo、Toshihiko Okamoto

  DOI：10.1016/s0040-4020(01)91336-5

  日期：1984.1

  The acid-catalyzed solvolysis of N-tosyl-O-arylhydroxylamines in aromatic solvents and the thermolysis of N-arylqxypyridinium salts involve common intermediates, phenoxenium ions, for the formation of hydroxybiphenyl derivatives. Diphenylethers are formed when the hydrolysis of the N—O bonds is slow and the aromatic solvent has high nucleophilicity.

  N-甲苯磺酰基-O-芳基羟胺在芳族溶剂中的酸催化溶剂分解和N-芳基氧代吡啶鎓盐的热分解涉及常见的中间体苯氧鎓离子，用于形成羟基联苯衍生物。当N-O键的水解缓慢且芳族溶剂具有高亲核性时，会形成二苯醚。
• 4-Substituted quinolines as antitumor agents
  申请人：Boyle Thomas Francis

  公开号：US20080027054A1

  公开（公告）日：2008-01-31

  The invention concerns compounds of formula (I), wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , R 10 m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumour disease.

  该发明涉及式(I)的化合物，其中R1、R2、R3、R4、R5、R6、R8、R9、R10、m、n、p、X、Y和Z的任何含义定义在说明中，它们的制备方法，包含它们的制药组合物，以及在制造用于治疗实体肿瘤疾病的抗增殖剂药物时使用它们的用途。
• Efficient Method for Demethylation of Aryl Methyl Ether Using Aliquat-336
  作者：Suresh B. Waghmode、Ganesh Mahale、Viraj P. Patil、Kartik Renalson、Dharmendra Singh

  DOI：10.1080/00397911.2013.772201

  日期：2013.12.17

  A rapid method for selective cleavage of aryl methylethers can be achieved in the presence of a protic acid and a catalytic amount of phase-transfer catalyst (Aliquat-336). Aliquat-336 accelerates the rate of reaction and affords the corresponding phenols in excellent to good yields on a wide variety of substrates. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]